Studi Literatur Potensi Antikanker Pada Daun Ungu (Graptophyllum Pictum (L.) Griff)
DOI:
https://doi.org/10.29313/bcsp.v3i2.9047Keywords:
graptophyllum pictum (L.) Griff, daun ungu, Antikanker, Studi literaturAbstract
Abstract. Purple leaves (Graptophyllum pictum (L.) Griff) is a plant that has many properties, including as a diuretic, menstrual stimulant, anti-inflammatory, constipation treatment, hemorrhoids, antireumatic, ulcer treatment, and also as a mild laxative. However, as an anticancer plant, not much research has been done. Therefore, research was carried out with a Systematic Literature Review to obtain more accurate information and also as a reference for researchers in developing new alternative treatments for cancer. This research was conducted to determine the potential of purple leaf (Graptophyllum pictum (L.) Griff) as anticancer, compounds contained in purple leaf (Graptophyllum pictum (L.) Griff) which have potential as anticancer, and also how the mechanism of these compounds in treating cancer. This research was conducted using the Systematic Literature Review method by collecting data through online search engines such as Google Scholar, Garuda Journal, Science Direct, Pubmed, Proquest, Sage Publication, and also Wiley Journal which were then analyzed to obtain 3 appropriate articles. The results showed the presence of phytol compounds, flavonoid which have potential as anticancer compounds in purple leaves (Graptophyllum pictum (L.) Griff).
Abstrak. Daun ungu (Graptophyllum pictum (L.) Griff) merupakan salah satu tanaman yang memiliki banyak khasiat, diantaranya ialah sebagai obat diuretik, pelancar haid, antiinflamasi, pengobatan sembelit, ambeien, antirematik, pengobatan bisul, dan juga sebagai pencahar ringan. Namun sebagai tanaman antikanker masih belum banyak dilakukan penelitian. Maka dari itu dilakukan penelitian dengan Systematic Literatur Review untuk memperoleh informasi yang lebih akurat dan juga sebagai referensi bagi peneliti dalam mengembangkan alternatif pengobatan baru untuk kanker. Penelitian ini dilakukan untuk mengetahui potensi daun ungu (Graptophyllum pictum (L.) Griff) sebagai antikanker, senyawa yang terkandung dalam daun ungu (Graptophyllum pictum (L.) Griff) yang memiliki potensi sebagai antikanker, dan juga bagaimana mekanisme dari senyawa tersebut dalam mengatasi kanker. Penelitian ini dilakukan dengan menggunakan metode Systematic Literatur Review dengan melakukan pengambilan data melalui mesin pencari online seperti Google Scholar, Garuda Jurnal, Science Direct, Pubmed, Proquest, Sage Publication, dan juga Wiley Journal yang kemudian dianalisis sehingga didapatkan 3 artikel yang sesuai. Hasil penelitian menunjukkan adanya senyawa fitol, dan flavonoid yang memiliki potensi sebagai senyawa antikanker pada daun ungu (Graptophyllum pictum (L.) Griff).
References
[2] M. Dewi, “Sebaran Kanker di Indonesia, Riset Kesehatan Dasar 2007,” Indones. J. Cancer, vol. 11, no. 1, p. 1, 2017, doi: 10.33371/ijoc.v11i1.494.
[3] I. Kementerian Kesehatan Republik, Profil Kesehatan Indonesia Tahun 2015. Jakarta: Kemenkes RI, 2015.
[4] L. H. Siwi and A. Zuhrotun, “Artikel Tinjauan : Tanaman Indonesia Yang Berpotensi Sebagai Antikanker,” Farmaka, vol. 4, pp. 1–15, 2019.
[5] B. Defrikson, G. K. Dewa, S. K. Vanda, V. Y. Y. Paulina, and R. J. R. Max, “Analisis Fitokimia dan Uji Toksisitas Daun Leleng Merah ( Graptophyllum pictum ( L .) Griffith ) dengan Metode Brine Shrimp Lethality Test Phytochemical Analysis and Toxicity Test of Leleng Merah Leaves ( Graptophyllum pictum ( L . ) Griffith ) Using the,” vol. 20, no. 2, pp. 122–127, 2020.
[6] T. da S. Agostini-Costa, F. R. Vieira, H. R. Bizzo, D. Silveira, and M. A. Gimenes, “Secondary Metabolites,” Compr. Biotechnol. Second Ed., vol. 1, pp. 155–167, 2011, doi: 10.1016/B978-0-08-088504-9.00018-0.
[7] L. Botahala et al., Deteksi Dini Metabolit Sekunder pada Tanaman. Sumatra Barat: CV. Mitra Cendekia Media, 2020. [Online]. Available: http://repo.untribkalabahi.ac.id/xmlui/handle/123456789/315
[8] J. Zarah and V. No, “Struktur , Bioaktivitas Dan Antioksidan Flavonoid Structure , Bioactivity And Antioxidant Of Flavonoid,” vol. 6, no. 1, pp. 21–29, 2018.
[9] N. Azwanida, “A Review on the Extraction Methods Use in Medicinal Plants, Principle, Strength and Limitation,” Med. Aromat. Plants, vol. 04, no. 03, pp. 3–8, 2015, doi: 10.4172/2167-0412.1000196.
[10] S. Amirah, “Uji Efek Antimitosis Ekstrak Etanol Daun Wungu (Graptophyllum pictum (L.) Griff) Dengan Metode Penghambatan Pembelahan Sel Telur (Tripneustes gratilla L.) Terfertilisasi,” J. Ilm. As-Syifaa, vol. 7, no. 1, pp. 43–51, 2015, doi: 10.33096/jifa.v7i1.19.
[11] A. Aminah, A. Muflihunna, and Z. Abidin, “Uji Aktivitas Antioksidan Fraksi Etil Asetat Daun Wungu (Graptophyllum pictum (L.) Griff) Dengan Menggunakan Metode FRAP (Ferric Reducing Antioxidant Power),” J. Ilm. As-Syifaa, vol. 8, no. 1, pp. 39–44, 2016, doi: 10.33096/jifa.v8i1.156.
[12] A. Amin, P. Gani, Andayana, and R. Murwanti, “Aktivitas sitotoksik dari (Graptophyllum pictum ( L .) Griff) Etanolik Ekstrak dan Fraksinya pada Sel Kanker Usus Manusia WiDr,” vol. 25, no. April, pp. 29–33, 2020.
[13] W. H. O. WHO, “Cancer,” 2022. [Online]. Available: https://www.who.int/en/news-room/fact-sheets/detail/cancer
[14] F. E. Pratama and R. F. Nuwarda, “Review: Senyawa Aktif Antikanker Dari Bahan Alam Dan Aktivitasnya,” Rev. Senyawa Aktif Antika Ka, vol. 16, pp. 149–158, 2018.
[15] S. Natalia Saragih, M. Pandapotan Nasution, H. Munandar Nasution, and R. Yuniarti, “Skrinning Fitokimia Dan Uji Sitotoksisitas Ekstrak Etanol Daun Ungu (Graptophyllum pictum (L.) Griff) Dengan Metode BSLT Phytochemical Screening And Cytotoxicity Test Of Daun Ungu (Graptophyllum pictum (L.) Griff) Ethanol Extract With BSLT Method,” vol. 2, no. 2, pp. 170–177, 2023.
[16] J. Nadechanok et al., “The chemical constituents and the cytotoxicity, antioxidant and antibacterial activities of the essential oil of Graptophyllum pictum (L.) Griff,” J. Essent. Oil-Bearing Plants, vol. 18, no. 1, pp. 11–17, 2015, doi: 10.1080/0972060X.2014.935036.
[17] P. Maningkas, D. Pandiangan, and F. Kandou, “Uji Antikanker dan Antioksidan Ekstrak Metanol Daun Pasote (Dysphania ambrosioides L.) Anticancer and Antioxidant Test of Methanol Extract of Epazote leaves (Dysphania ambrosioides L.),” J. Bios Logos, vol. 9, no. 2, p. 102, 2019, doi: 10.35799/jbl.9.2.2019.24556.
[18] J. Nadechanok et al., “Phytochemical screening, phenolic and flavonoid contents, antioxidant and cytotoxic activities of Graptophyllum pictum (L.) Griff,” Chiang Mai J. Sci., vol. 44, no. 1, pp. 193–202, 2017.
[19] S. N. Harahap and Nurbaity Situmorang, “Skrinning Fitokimia Dari Senyawa Metabolit Sekunder Buah Jambu Biji Merah (Psidium guajava L.),” EduMatSains J. Pendidikan, Mat. dan Sains, vol. 5, no. 2, pp. 153–164, 2021, doi: 10.33541/edumatsains.v5i2.2204.
[20] A. Susanty, “In Vitro Cytotoxic Activity Test of Tampa Badak (Voacanga foetida (Blume) Leaves on L1210 Leukemia,” J. Sains Farm. Klin., vol. 8, no. 3, p. 323, 2021, doi: 10.25077/jsfk.8.3.323-331.2021.
[21] P. S. Sirait and I. Setyaningsih, “Aktivitas Antikanker Ekstrak Spirulina yang Dikultur Pada Media,” Jphpi, vol. 22, no. 1, pp. 50–59, 2019.
[22] K. P. Y. Harhari, S. Supriatno, and A. Medawati, “Daya Hambat Ekstrak Etanol Daun Keladi Tikus (Typhonium flagelliforme Lodd.) terhadap Proliferasi Sel Kanker Lidah Manusia (Sp-c1) secara In Vitro The Inhibition of Ethanolic Extract of Typhonium flagelliforme Lodd. Leaves toward Cell Proliferation of Hum,” Mutiara Med. J. Kedokt. dan Kesehat., vol. 11, no. 1, pp. 14–18, 2011.
[23] P. M. Wuni, K. Madyaningrana, and V. C. Prakasita, “Efek Ekstrak Daun Bayam Brasil (Alternanthera sissoo hort) Terhadap Jumlah Limfosit dan Indeks Organ Timus dan Limpa Mencit Jantan,” Metamorf. J. Biol. Sci., vol. 9, no. 2, p. 397, 2022, doi: 10.24843/metamorfosa.2022.v09.i02.p19.
