Pengembangan Sediaan Spray Litter Ekstrak Daun Sirih (Piper Betle L.) sebagai Antiparasit pada Pasir Kucing
DOI:
https://doi.org/10.29313/bcsp.v6i2.26117Keywords:
Toxoplasma gondii, Spray litter, Ekstrak daun sirih hijauAbstract
Abstract. Toxoplasma gondii is a parasite that causes toxoplasmosis, which requires efforts to prevent environmental contamination. Green betel leaf (Piper betle L.) contains secondary metabolite compounds that have the potential as antiparasitic. This study aims to formulate and produce physical characteristics of green betel leaf ethanol extract. This study was conducted experimentally through characterization, phytochemical screening, spray litter formulation with concentrations of 0.25%, 0.5%, and 1%, as well as evaluation of organoleptic preparations, homogeneity, pH, spreadability, specific gravity, physical stability, and observation of cat acceptance of the use of the litter box. The results showed that the characterization of the simplicia and extract generally met the quality requirements, except for the ash content of the simplicia which was insoluble in acid. All formulas met the physical parameters, at a concentration of 1%, sediment formation occurred after storage and was less acceptable to cats. The 0.5% formula was chosen as the best formula because it had good physical stability. Thus, the ethanol extract of green betel leaves can be formulated into a liter spray preparation that meets the physical evaluation parameters of the preparation at concentrations of 0.25% and 0.5% as a basis for further research related to controlling Toxoplasma gondii contamination.
Abstrak. Toxoplasma gondii merupakan parasit penyebab toksoplasmosis yang memerlukan upaya pencegahan kontaminasi lingkungan. Daun sirih hijau (Piper betle L.) mengandung senyawa metabolit sekunder berpotensi sebagai antiparasit. Penelitian ini bertujuan memformulasikan dan mengevaluasi karakteristik fisik sediaan ekstrak etanol daun sirih hijau. Penelitian ini dilakukan secara eksperimental melalui karakterisasi, penapisan fitokimia, formulasi spray litter dengan konsentrasi 0,25%;0,5%; dan 1%, serta evaluasi sediaan organoleptik, homogenitas, pH, daya sebar, bobot jenis, stabilitas fisik, dan pengamatan penerimaan kucing terhadap penggunaan litter box. Hasil menunjukan bahwa karakterisasi simplisia dan ekstrak umumnya memenuhi persyaratan mutu, kecuali kadar abu tidak larut asam simplisia. Seluruh formula memenuhi parameter fisik, pada konsentrasi 1% terjadi pembentukan endapan setelah penyimpanan dan kurang diterima kucing. Formula 0,5% dipilih sebagai formula terbaik karena memiliki stabilitas fisik yang baik. Dengan demikian, ekstrak etanol daun sirih hijau dapat diformulasikan menjadi sediaan spray litter yang memenuhi parameter evaluasi fisik sediaan pada konsentrasi 0,25% dan 0,5% sebagai dasar penelitian lanjutan terkait pengendalian kontaminasi Toxoplasma gondii
References
Bheja, Angelina Sulistia, Tri Utami, and Tarsisius C. Tophianong. 2022. “IDENTIFIKASI KRISTALURIA SEBAGAI GAMBARAN KELURAHAN LILIBA.” Jurnal Veteran Nusantara 5(08):1–10.
Depkes RI, 2017. 2017. “Farmakope Herbal Indonesia Edisi II.” 163–67. doi:10.1201/b12934-13.
Eawsakul, Komgrit, Wiyada Kwanhian Klangbud, Phirabhat Saengsawang, Tassanee Ongtanasup, Kunchaphorn Ratchasong, Ratchadaporn Boripun, Veeranoot Nissapatorn, Maria de Lourdes Pereira, Conny Turni, Fonthip Makkliang, Kawalin Pumbut, and Watcharapong Mitsuwan. 2025. “Bactericidal and Antibiofilm Activities of Piper Betle Extract against Burkholderia Pseudomallei: In Vitro and in Silico Approaches.” Biofouling 41(1):36–51. doi:10.1080/08927014.2024.2438689.
Elsheikha, Hany M., Christina M. Marra, and Xing Quan Zhu. 2020. “Epidemiology, Pathophysiology, Diagnosis, and Management of Cerebral Toxoplasmosis.” Clinical Microbiology Reviews 34(1):1–28. doi:10.1128/CMR.00115-19.
Fitra, Romadhonsyah, Aisha Nanda Caela Amry, Annisa Fitria, and Arde Toga Nugraha. 2024. “AKTIVITAS ANTIBAKTERI DAN ANTIBIOFILM DARI EKSTRAK DAUN BANGUN-BANGUN (Coleus Amboinicus L.) TERHADAP BAKTERI Staphylococcus Aureus.” Jurnal Ilmiah Ibnu Sina (JIIS) Ilmu Farmasi Dan Kesehatan 9(2):419-430. doi:10.36387/jiis.v9i2.2173.
Handayani, Fitri, Anita Apriliana, and Hellen Natalia. 2019. “KARAKTERISASI DAN SKRINING FITOKIMIA SIMPLISIA DAUN SELUTUI PUKA (Tabernaemontana Macracarpa Jack).” Jurnal Ilmiah Ibnu Sina 4(1):49–58.
Juariah, Siti, Sri Kartini, and Yulinda Wardani. 2021. “Uji Laboratorium Efektivitas Ekstrak Etanol Daun Brotowali Sebagai Insektisida Terhadap Nyamuk Aedes Aegypti Di Universitas Abdurrab Pekanbaru Laboratory Test of the Effectiveness of Brotowali Leaf Ethanol Extract as Insecticide against Aedes Aegypti Mosq.” Jurnal Penelitian Poltekkes Kemenkes Kendari, Indonesia 13. no. 1:39–44.
Khoirani, Nur. 2000. Karakteristik Simplisia Dan Standarisasi Ekstrak Etanol Herbal Kemangi (Ocimum Americanum L.).
Kiko, Paskalis Trianus, Wintari Taurina, and Mohamad Andrie. 2023. “Karakterisasi Proses Pembuatan Simplisia Daun Sirih Hijau ( Piper Betle ) Sebagai Sediaan Obat Penyembuhan Luka.” Indonesian Journal of Pharmaceutical Education 3(1):16–25. doi:10.37311/ijpe.v3i1.18808.
Latifa, Nabila Nur, Lanny Mulqie, Siti Hazar, Prodi Farmasi, Fakultas Matematika, Pengetahuan Alam, and Universitas Islam Bandung. 2022. “Penetapan Kadar Sari Larut Air Dan Kadar Sari Larut Etanol Simplisia Buah Tin ( Ficus Carica L .).” Bandung Conference Series: Pharmacy Vol 2, No.:1–4.
Laurentius, Marcus, Yudhi Purwoko, and Partomuan Simanjuntak. 2020. “Standardisasi Parameter Spesifik Dan Nonspesifik Ekstrak Etanol Daun Kelor ( Moringa Oleifera ) Asal Kabupaten Blora.” JSainstech Farma Jurnal Ilmu Kefarmasian 13(2):124–29.
Maulana, Fahmi Alief, Anita Sukmawati, Ahmad Fauzi, and Arifah Sri Wahyuni. 2024. “Formulasi Dan Penilaian Fisik Sediaan Spray Minyak Kemiri ( Aleurites Moluccana ( L .) Wild ) Dan Seledri ( Apium Graveolens ) Sebagai Pertumbuhan Rambut.” Jurnal Pharmascience 11(2):284–303.
Mohandas, Anu, Hongrong Luo, and Seeram Ramakrishna. 2021. “An Overview on Atomization and Its Drug Delivery and Biomedical Applications.” Applied Sciences (Switzerland) 11(11). doi:10.3390/app11115173.
Montoya, J. G., and O. Liesenfeld. 2004. “Toxoplasmosis.” Lancet 363(9425):1965–76. doi:10.1016/S0140-6736(04)16412-X.
Muhammad Ichsan Nurfahmi, Kiki Mulkiya Yuliawati, and Livia Syafnir. 2024. “Pengujian Pengaruh Perbedaan Metode Ekstraksi Terhadap Parameter Standar Mutu Ekstrak Daun Kelor.” Jurnal Riset Farmasi 83–90. doi:10.29313/jrf.v4i2.5198.
Pereira Filho, Adalberto Alves, Mariana Maciel Cunha, Mariana Alves Stanton, Lydia Fumiko Yamaguchi, Massuo Jorge Kato, and Érica S. Martins-Duarte. 2023. “In Vitro Activity of Essential Oils from Piper Species (Piperaceae) against Tachyzoites of Toxoplasma Gondii.” Metabolites 13(1). doi:10.3390/metabo13010095.
Priyadi, Agus, Fatur Rahman Harun, and Anny Sartika Daulay. 2020. “Comparison of Maceration and Soxhlet Extraction on the Total Phenolic Content of Ethanol Extract of Betel Leaves (Piper Betle L.) Using Visible Spectrophotometry. Perbandingan Metode Ekstraksi Maserasi Dan Sokletasi Terhadap Kadar Fenolik Total Ekstrak Et.” Journal of Pharmaceutical and Sciences Electronic 2025(1):550–63. https://doi.org/10.36490/journal-jps.com.
Putri, Anandita Tania, Arum Suproborini, and Desi Kusumawati. 2023. “Kandungan Metabolit Sekunder Ekstrak Etanol Daun Sirih Hijau (Piper Betle L.).” Seminar Nasional Prodi Farmasi 226–29.
Robert-Gangneux, Florence, and Marie Laure Dardé. 2012. “Epidemiology of and Diagnostic Strategies for Toxoplasmosis.” Clinical Microbiology Reviews 25(2):264–96. doi:10.1128/CMR.05013-11.
Siagian, Irvina M. Nuh, Ulfayani Mayasari, and Rizki Amelia Nasution. 2025. “Optimasi Formula Salep Ekstrak Daun Sirih Hijau ( Piper Betle L . ) Sebagai Antijamur Terhadap Candida Albicans Dan Malassezia Furfur Secara in-Vitro.” Filogeni : Jurnal Mahasiswa Biologi 5(3):218–31.
SOARES, NOBERTO. 2021. “PENGARUH METODE DAN PELARUT EKSTRAKSI TERHADAP MUTU EKSTRAK DAUN KARIKA (Carica Pubescens L.).” Indonesian Journal of Pharmacy and Natural Product 7–10.
Suryani, Nelly, Ismiarni Komala, Luthfia Wikhdatul Akhsani, Sabrina Dahlizar, and Ofa Suzanti. 2024. “Physical-Chemical Stability Test on Spray Gel with Active Compound Ethyl p-Methoxycinnamate ( Kaempferia Galanga Linn .) And Menthol , Using Combination Gelling Agent Na Cmc and Copovidone.” Indonesian Journal of Pharmaceutical Science 22(1):307–21.
