Optimasi Sintesis Nanopartikel Tembaga (CuNPs) Menggunakan Bioreduktor Daun Katuk
DOI:
https://doi.org/10.29313/bcsp.v6i2.25739Keywords:
Daun katuk, CuNPs, Green synthesisAbstract
Abstract. Synthesis of copper nanoparticles (CuNPs) using green synthesis method is an environmentally friendly alternative that utilizes natural bioreductors from plants. This study aims to synthesize and characterize CuNPs by utilizing the secondary metabolite content of Sweet leaf bush extract (Sauropus androgynus(L.)Merr) such as flavonoids, polyphenols and saponins as reducing agents and stabilizers. The success of CuNPs formation is indicated by the results of UV-Vis spectrophotometry which shows a specific absorption peak of Surface Plasmon Resonance (SPR) at a wavelength of 653 nm. FTIR analysis shows a shift in the O-H functional group band to 3114.62cm-1 and the emergence of a new C-O band at 1095.46 cm-1, proving the attachment of phytochemical compounds to the surface of nanoparticles. Measurements using PSA produce an average particle size of 111.3 nm with an average PDI of 0.2132. The particle size exceeds the ideal range due to the high precursor concentration and the occurrence of slight aggregation. Based on the research results, the Sweet Leaf bushextract used still requires optimization to produce smaller nanoparticle sizes for CuNPs synthesis using the green synthesis method.
Abstrak. Sintesis nanopartikel tembaga (CuNPs) menggunakan metode green synthesis menjadi alternatif yang ramah lingkungan yang memanfaatkan bioreduktor alami dari tumbuhan. Penelitian ini bertujuan untuk mensintesis dan mengkarakterisasi CuNPs dengan memanfaatkan kandungan metabolit sekunder sari ekstrak daun katuk (Sauropus androgynus(L.)Merr) seperti flavonoid, polifenol dan saponin sebagai agen pereduksi sekaligus penstabil. Keberhasilan pembentukan CuNPs ditandai dengan hasil spektrofotometri UV-Vis yang menunjukkan puncak serapan spesifik Surface Plasmon Resonance (SPR) pada panjang gelombang 653 nm. Analisis FTIR menunjukkan pergeseran pita gugus fungsi O-H menjadi 3114,62cm-1 dan munculnya pita baru C-O pada 1095,46 cm-1, membuktikan keterikatan senyawa fitokimia pada permukaan nanopartikel. Pengukuran menggunakan PSA menghasilkan rata-rata ukuran partikel sebesar 111,3 nm dengan rata-rata PDI 0.2132. Ukuran partikel tersebut melebihi rentang ideal akibat konsentrasi prekursor yang tinggi dan terjadinya sedikit agregasi. Berdasarkan hasil penelitian, ekstrak daun katuk yang digunakan masih perlu dilakukan optimasi untuk menghasilkan ukuran nanopartikel yang lebih kecil dalam sintesis CuNPs melalui metode green synthesis.
References
Abdelhai, M. F., Shabaan, R. H., Kamal, N. M., Elemary, E. A., Abd-Elhalim, B. T., & Hassan, E. A. (2024). Copper nanoparticles biosynthesis by Stevia rebaudiana extract: biocompatibility and antimicrobial application. AMB Express, 14(1). https://doi.org/10.1186/s13568-024-01707-2
Adewale Akintelu, S., Kolawole Oyebamiji, A., Charles Olugbeko, S., & Felix Latona, D. (2021). Green chemistry approach towards the synthesis of copper nanoparticles and its potential applications as therapeutic agents and environmental control. Current Research in Green and Sustainable Chemistry, 4(July), 100176. https://doi.org/10.1016/j.crgsc.2021.100176
Aryani, A. D., & Wisnuwardhani, H. A. (2022). Studi Literatur Sintesis Nanopartikel Tembaga menggunakan Bioreduktor Ekstrak Tumbuhan dengan Aktivitas Antioksidan Pendahuluan Sintesis nanopartikel merupakan salah satu bagian dari nanoteknologi dan aplikasinya . Nanopartikel mikroorganisme sebagai agen. 2, 41–48. https://doi.org/https://doi.org/10.29313/jrf.v2i1.843
Aulia Debby Pelu, Risman Tunny, & Bilkis Latuconsina. (2020). Skrining fitokimia dan uji aktivitas antibakteri ekstrak etanol bulu babi (diadema setosum) terhadap pertumbuhan Staphylococcus aureus DI PERAIRAN DESA PELAUW. Jurnal Sains Dan Kesehatan, 4(2), 01–15. https://doi.org/10.57214/jusika.v4i2.133
Azad, A., Zafar, H., Raza, F., & Sulaiman, M. (2023). Factors Influencing the Green Synthesis of Metallic Nanoparticles Using Plant Extracts: A Comprehensive Review. Pharmaceutical Fronts, 5(3), E117–E131. https://doi.org/10.1055/s-0043-1774289
Baba, I. A., Awe, O. B., Mustapha, S., Abubakar, M. A., Abdulkareem, A. S., Tijani, J. O., & Obayomi, K. S. (2026). Influence of plant-derived extracts on the synthesis, physicochemical properties, and applications of metal and metal oxide nanoparticles. Hybrid Advances, 13(April). https://doi.org/10.1016/j.hybadv.2026.100666
Badriyah, L., & Farihah, D. (2023). Optimalisasi ekstraksi kulit bawang merah (Allium cepa L) menggunakan metode maserasi. Jurnal Sintesis: Penelitian Sains, Terapan Dan Analisisnya, 3(1), 30–37. https://doi.org/10.56399/jst.v3i1.32
Bissa, S., Naruka, P., & Birthlya, R. (2026). Effect of Amount of Leaf Extract and Precursor Salt on Green Synthesis of ZnO Nanoparticles : A Comparative Study ( UV – Vis ,. 04(3), 51–54. https://doi.org/10.61343/jcm.v4i01.200
Chain, S., Technology, P., Control, Q., Chief, E. I., Purwandari, U., Board, E., Supartono, W., Mada, U. G., Murkovic, M., Rardniyom, C., Fuad, M., Mu, F., Hidayat, K., Indarto, C., Editor, M., Firmansyah, R. A., Editor, A., Efendi, M., Iswanto, H., & Istighfarin, S. (2021). AGROINTEK : Jurnal Teknologi Industri Pertanian. PENANGANAN DAN PENERAPAN TEKNOLOGI PASCAPANEN TANAMAN OBAT, 15, 253–271. https://doi.org/10.21107/agrointek.v15i1.7661
Crisan, M. C., Teodora, M., & Lucian, M. (2022). Copper nanoparticles: Synthesis and characterization, physiology, toxicity and antimicrobial applications. Applied Sciences (Switzerland), 12(1). https://doi.org/10.3390/app12010141
Elisma, N., Emriadi, E., & Darmawi, A. (2023). Pengaruh Variasi Prekursor Terhadap Morfologi dan Aktivitas Antibakteri Nanopartikel Tembaga Menggunakan Reduktor Ekstrak Daun Gambir. REACTOR: Journal of Research on Chemistry and Engineering, 4(2), 68. https://doi.org/10.52759/reactor.v4i2.109
Eze, U. S., & James, A. O. (2025). UV-Vis, XRD, FTIR, SEM, and PSA-Based Characterization of Copper and Iron Nanoparticles Synthesized Using Spondias mombin (Hog Plum) Leaf Extract. ChemClass Journal, 9(2), 547–562. https://doi.org/10.33003/chemclas-2025-0902/178
Foliatini, & Nurdiani. (2019). One-Step Synthesis of Anisotropic Gold Nanoparticles with the Aid Extract from Wuluh Starfruit (Averrhoa Bilimbi) Fruit as Reducing and Morphology Controlling Agent. Oriental Journal Of Chemistry, 35(4), 1453–1462. https://doi.org/10.13005/ojc/350429
Hanna, D. H., Nady, D. S., Wasef, M. W., Fakhry, M. H., Mohamed, F. S., Isaac, D. M., Kirolos, M. M., Azmy, M. S., Hakeem, G. E., & Fathy, C. A. (2025). Plant-derived nanoparticles: Green synthesis, factors, and bioactivities. Next Materials, 9(September). https://doi.org/10.1016/j.nxmate.2025.101275
Irwan R, Muhammad Zakir, P. B. (2020). Sintesis Nanopartikel Perak dan Pengaruh Penambahan Asam p-Kumarat Untuk Aplikasi Deteksi Melamin. Indo. J. Chem. Res., 7(2), 141–150. https://doi.org/10.30598//ijcr.2020.7-irw
Ivan Charles S.Klau, Arista Wahyu Nigsih, & Waldo Farel Irvana Putra. (2022). Profil rendemen ekstrak dan fraksi kulit buah, daging buah dan buah pisang mentah (Musa paradisiaca L.). Journal of Pharmacy Science and Technology, Volume 3 N(1), 1–10.
Jadoun, S., Arif, R., Jangid, N. K., & Meena, R. K. (2021). Green synthesis of nanoparticles using plant extracts: a review. Environmental Chemistry Letters, 19(1), 355–374. https://doi.org/10.1007/s10311-020-01074-x
Jayadev, A., & Krishnan B, N. (2021). Green Synthesis of Copper Nanoparticles and its Characterization. Journal of Scientific Research, 65(01), 80–84. https://doi.org/10.37398/jsr.2021.650111
Khatimah, I. H. (2025). Kombinasi Ekstrak Daun Katuk ( Sauropus Androgynus L . Merr ) dan Daun Meniran ( Phylanthus Niruri L .) Terhadap Antioksidan Combination Extracts of Katuk Leaf ( Sauropus androgynus L . Merr ) and Meniran Leaf ( Phylanthusniruri L .) Against Antioxidant A. Jurnal Surya Medika (JSM), ll(3), 291–300. http://journal.umpalangkaraya.ac.id/index.php/jsm
Khoo, H., Azlan, A., & Ismaila, A. (2015). Sauropus androgynus Leaves for Health Benefits: Hype and the Science. The Natural Products Journal, 5(2), 115–123. https://doi.org/10.2174/221031550502150702142028
Kulikov, A. Y., & Novikov, I. V. (2017). Фармакоэкономические Аспекты Применения Препаратов Группы Агонистов Глюкагоноподобного Пептида-1 (Гпп-1) В Комбинации С Метформином При Сахарном Диабете 2 Типа. Pharmacoeconomics: Theory and Practice, 5(1), 84–84. https://doi.org/10.30809/phe.1.2017.21
Kumar, M., Kaushik, D., Kumar, A., Gupta, P., Proestos, C., Oz, E., Orhan, E., Kaur, J., Khan, M. R., Elobeid, T., Bordiga, M., & Oz, F. (2023). Green synthesis of copper nanoparticles from Nigella sativa seed extract and evaluation of their antibacterial and antiobesity activity. International Journal of Food Science and Technology, 58(6), 2883–2892. https://doi.org/10.1111/ijfs.16359
Longdong, I. A., Tooy, D., Rantung, R. A., Ransun, K., Pinatik, H., & Saroinsong, D. (2025). Karakteristik Pengeringan Jahe Merah ( Zingiber Officinale Var . Rubrum ) Menggunakan Alat Pengering Tipe Kubah. Karakteristik Pengeringan Jahe Merah (Zingiber Officinale Var. Rubrum) Menggunakan Alat Pengering Tipe Kubah, 16, 0–7. https://doi.org/10.21107/agrointek.v15i1.7661
Marslin, G., Siram, K., Maqbool, Q., Selvakesavan, R. K., Kruszka, D., Kachlicki, P., & Franklin, G. (2018). Secondary metabolites in the green synthesis of metallic nanoparticles. Materials, 11(6), 1–25. https://doi.org/10.3390/ma11060940
Mita, F., Jumarni, A., Wati, R., Patimah, A., & Rahman, D. Y. (2024). Perkembangan Penerapan Nanoteknologi di Bidang Pelapisan (Coating) Development of Applied Nanotechnology in Coating. Jurnal Penelitian Fisika Dan Terapannya (Jupiter), 5(2), 1–29. https://doi.org/10.31851/jupiter.v5i2.33738
Miu, B. A., & Dinischiotu, A. (2022). New Green Approaches in Nanoparticles Synthesis: An Overview. Molecules, 27(19). https://doi.org/10.3390/molecules27196472
Mourdikoudis, S., Pallares, R. M., & Thanh, N. T. K. (2018). Characterization techniques for nanoparticles: Comparison and complementarity upon studying nanoparticle properties. Nanoscale, 10(27), 12871–12934. https://doi.org/10.1039/c8nr02278j
Ningsih, A. W., Jihan Fahiroh Nur Arifin, Retno Wulan Devitri, Rusdiana Tri Septiarini, Elvira Silvany Zahara, Vira Maulidya, Yasmine Eka Maulidya, Elly Eka Rahmawati, Zakkiya Sabila, Zahratul Humaidah, & Ivan Charles S.Klau. (2025). Tinjauan Literatur: Efektivitas Maserasi sebagai Metode Ekstraksi Fitokimia. OBAT: Jurnal Riset Ilmu Farmasi Dan Kesehatan, 3(6), 228–242. https://doi.org/10.61132/obat.v3i6.1927
Pourmadadi, M., Holghoomi, R., Shamsabadipour, A., Maleki-baladi, R., Rahdar, A., & Pandey, S. (2024). Copper nanoparticles from chemical, physical, and green synthesis to medicinal application: A review. Plant Nano Biology, 8(December 2023), 100070. https://doi.org/10.1016/j.plana.2024.100070
Qomariyah, A., Wulandari, E. Y., & Najib, A. (2025). Sintesis dan Karakterisasi Nanopartikel CuO-Kitosan serta Uji Antibakteri terhadap Streptococcus pneumoniae. Indonesian Journal of Chemical Research, 10(1). https://doi.org/10.20885/ijcr.vol10.iss1.art2
Rahayu, N., & Ardigurnita, F. (2021). Potential of Katuk Leaves As Lowering Fat Levels in Poultry. Jurnal Ilmu Pertanian Dan Peternakan, 9(2), 136–139. https://doi.org/https://doi.org/10.31949/agrivet.v9i2.1697
Ramadhan, H., Andina, L., Yuliana, K. A., Baidah, D., & Lestari, N. P. (2020). Phytochemical screening and rendemen comparison of 96% ethanol extract of terap (Artocarpus odoratissimus Blanco) leaf, flesh and peel / Skrining fitokimia dan perbandingan rendemen ekstrak etanol 96% daun, buah, dan kulit buah terap (Artocarpus odoratiss. Jurnal Ilmiah Farmako Bahari, vol 11, 103–112. https://journal.uniga.ac.id/index.php/JFB
Salim, R., Taslim, T., Selonni, F., Verawaty, V., & Dewi, I. P. (2025). Decoction of Cocos nucifera Linn. : Antioxidant Activity, Total Phenolics, and Flavonoids Contents. Indonesian Journal of Pharmaceutical Science and Technology, 12(2), 129–136. https://doi.org/10.24198/ijpst.v12i2.45058
Selvam, M. S., Tresina, P. S., Mohan, V. R., Rani, S. A., & Jeeva, S. (2025). Eco-friendly fabrication and characterization of copper nanoparticles via Cymodocea serrulata (R.Br.) Asch. & Magnus extract: Evaluation of antioxidant and antibacterial activities. Next Materials, 9(October 2024), 100963. https://doi.org/10.1016/j.nxmate.2025.100963
Syahadat, A., & Siregar, N. (2020). Phytochemical Screening of Katuk Leaves (Sauropus androgynus) as a Lactation Promoter. Jurnal Kesehatan Ilmiah Indonesia, 5(1), 85–89.
Villagrán, Z., Anaya-Esparza, L. M., Velázquez-Carriles, C. A., Silva-Jara, J. M., Ruvalcaba-Gómez, J. M., Aurora-Vigo, E. F., Rodríguez-Lafitte, E., Rodríguez-Barajas, N., Balderas-León, I., & Martínez-Esquivias, F. (2024). Plant-Based Extracts as Reducing, Capping, and Stabilizing Agents for the Green Synthesis of Inorganic Nanoparticles. Resources, 13(6). https://doi.org/10.3390/resources13060070
Widwiastuti, H., Malang, P. K., & Ukuran, P. (2022). Pengaruh ukuran simplisia dan lama kontak pada ekstraksi senyawa aktif simplisia kayu jawa ( lannea coromandelica ) menggunakan metode maserasi effect of simplisia size and contact time on the extraction of active compounds of kayu jawa simplisia ( lannea. Effect of simplisia size and contact time on the extraction of active compounds of kayu jawa simplisia (lannea coromandelica) using the maceration method, 19, 86–90.
wina safutri, dewi damayanti abdulkarim, merly fevinia. (2015). Abstrak Skrining fitokimia merupakan metode yang digunakan untuk mempelajari komponen contained in samples , namely their chemical structure , biosynthesis , natural compositions of various types of plants . Several types of plants used by people in turme. Farmasi, 23–27. http://journal.aisyahuniversity.ac.id/index.php/JFA%0ASKRINING
Yusuf, A., Almotairy, A. R. Z., Henidi, H., Alshehri, O. Y., & Aldughaim, M. S. (2023). Nanoparticles as Drug Delivery Systems: A Review of the Implication of Nanoparticles’ Physicochemical Properties on Responses in Biological Systems. Polymers, 15(7), 1–26. https://doi.org/10.3390/polym15071596
Zambare, P., Survase, A., & Kanase, S. (2022). Green Synthesis of Copper Nanoparticles Using Leaf Extract of Ocimum sanctum and its Antimicrobial Activity. International Journal of Pharmaceutical Investigation, 13(1), 106–112. https://doi.org/10.5530/223097131692
Adewale Akintelu, S., Kolawole Oyebamiji, A., Charles Olugbeko, S., & Felix Latona, D. (2021). Green chemistry approach towards the synthesis of copper nanoparticles and its potential applications as therapeutic agents and environmental control. Current Research in Green and Sustainable Chemistry, 4(July), 100176. https://doi.org/10.1016/j.crgsc.2021.100176
Aryani, A. D., & Wisnuwardhani, H. A. (2022). Studi Literatur Sintesis Nanopartikel Tembaga menggunakan Bioreduktor Ekstrak Tumbuhan dengan Aktivitas Antioksidan Pendahuluan Sintesis nanopartikel merupakan salah satu bagian dari nanoteknologi dan aplikasinya . Nanopartikel mikroorganisme sebagai agen. 2, 41–48. https://doi.org/https://doi.org/10.29313/jrf.v2i1.843
Aulia Debby Pelu, Risman Tunny, & Bilkis Latuconsina. (2020). Skrining fitokimia dan uji aktivitas antibakteri ekstrak etanol bulu babi (diadema setosum) terhadap pertumbuhan Staphylococcus aureus DI PERAIRAN DESA PELAUW. Jurnal Sains Dan Kesehatan, 4(2), 01–15. https://doi.org/10.57214/jusika.v4i2.133
Azad, A., Zafar, H., Raza, F., & Sulaiman, M. (2023). Factors Influencing the Green Synthesis of Metallic Nanoparticles Using Plant Extracts: A Comprehensive Review. Pharmaceutical Fronts, 5(3), E117–E131. https://doi.org/10.1055/s-0043-1774289
Baba, I. A., Awe, O. B., Mustapha, S., Abubakar, M. A., Abdulkareem, A. S., Tijani, J. O., & Obayomi, K. S. (2026). Influence of plant-derived extracts on the synthesis, physicochemical properties, and applications of metal and metal oxide nanoparticles. Hybrid Advances, 13(April). https://doi.org/10.1016/j.hybadv.2026.100666
Badriyah, L., & Farihah, D. (2023). Optimalisasi ekstraksi kulit bawang merah (Allium cepa L) menggunakan metode maserasi. Jurnal Sintesis: Penelitian Sains, Terapan Dan Analisisnya, 3(1), 30–37. https://doi.org/10.56399/jst.v3i1.32
Bissa, S., Naruka, P., & Birthlya, R. (2026). Effect of Amount of Leaf Extract and Precursor Salt on Green Synthesis of ZnO Nanoparticles : A Comparative Study ( UV – Vis ,. 04(3), 51–54. https://doi.org/10.61343/jcm.v4i01.200
Chain, S., Technology, P., Control, Q., Chief, E. I., Purwandari, U., Board, E., Supartono, W., Mada, U. G., Murkovic, M., Rardniyom, C., Fuad, M., Mu, F., Hidayat, K., Indarto, C., Editor, M., Firmansyah, R. A., Editor, A., Efendi, M., Iswanto, H., & Istighfarin, S. (2021). AGROINTEK : Jurnal Teknologi Industri Pertanian. PENANGANAN DAN PENERAPAN TEKNOLOGI PASCAPANEN TANAMAN OBAT, 15, 253–271. https://doi.org/10.21107/agrointek.v15i1.7661
Crisan, M. C., Teodora, M., & Lucian, M. (2022). Copper nanoparticles: Synthesis and characterization, physiology, toxicity and antimicrobial applications. Applied Sciences (Switzerland), 12(1). https://doi.org/10.3390/app12010141
Elisma, N., Emriadi, E., & Darmawi, A. (2023). Pengaruh Variasi Prekursor Terhadap Morfologi dan Aktivitas Antibakteri Nanopartikel Tembaga Menggunakan Reduktor Ekstrak Daun Gambir. REACTOR: Journal of Research on Chemistry and Engineering, 4(2), 68. https://doi.org/10.52759/reactor.v4i2.109
Eze, U. S., & James, A. O. (2025). UV-Vis, XRD, FTIR, SEM, and PSA-Based Characterization of Copper and Iron Nanoparticles Synthesized Using Spondias mombin (Hog Plum) Leaf Extract. ChemClass Journal, 9(2), 547–562. https://doi.org/10.33003/chemclas-2025-0902/178
Foliatini, & Nurdiani. (2019). One-Step Synthesis of Anisotropic Gold Nanoparticles with the Aid Extract from Wuluh Starfruit (Averrhoa Bilimbi) Fruit as Reducing and Morphology Controlling Agent. Oriental Journal Of Chemistry, 35(4), 1453–1462. https://doi.org/10.13005/ojc/350429
Hanna, D. H., Nady, D. S., Wasef, M. W., Fakhry, M. H., Mohamed, F. S., Isaac, D. M., Kirolos, M. M., Azmy, M. S., Hakeem, G. E., & Fathy, C. A. (2025). Plant-derived nanoparticles: Green synthesis, factors, and bioactivities. Next Materials, 9(September). https://doi.org/10.1016/j.nxmate.2025.101275
Irwan R, Muhammad Zakir, P. B. (2020). Sintesis Nanopartikel Perak dan Pengaruh Penambahan Asam p-Kumarat Untuk Aplikasi Deteksi Melamin. Indo. J. Chem. Res., 7(2), 141–150. https://doi.org/10.30598//ijcr.2020.7-irw
Ivan Charles S.Klau, Arista Wahyu Nigsih, & Waldo Farel Irvana Putra. (2022). Profil rendemen ekstrak dan fraksi kulit buah, daging buah dan buah pisang mentah (Musa paradisiaca L.). Journal of Pharmacy Science and Technology, Volume 3 N(1), 1–10.
Jadoun, S., Arif, R., Jangid, N. K., & Meena, R. K. (2021). Green synthesis of nanoparticles using plant extracts: a review. Environmental Chemistry Letters, 19(1), 355–374. https://doi.org/10.1007/s10311-020-01074-x
Jayadev, A., & Krishnan B, N. (2021). Green Synthesis of Copper Nanoparticles and its Characterization. Journal of Scientific Research, 65(01), 80–84. https://doi.org/10.37398/jsr.2021.650111
Khatimah, I. H. (2025). Kombinasi Ekstrak Daun Katuk ( Sauropus Androgynus L . Merr ) dan Daun Meniran ( Phylanthus Niruri L .) Terhadap Antioksidan Combination Extracts of Katuk Leaf ( Sauropus androgynus L . Merr ) and Meniran Leaf ( Phylanthusniruri L .) Against Antioxidant A. Jurnal Surya Medika (JSM), ll(3), 291–300. http://journal.umpalangkaraya.ac.id/index.php/jsm
Khoo, H., Azlan, A., & Ismaila, A. (2015). Sauropus androgynus Leaves for Health Benefits: Hype and the Science. The Natural Products Journal, 5(2), 115–123. https://doi.org/10.2174/221031550502150702142028
Kulikov, A. Y., & Novikov, I. V. (2017). Фармакоэкономические Аспекты Применения Препаратов Группы Агонистов Глюкагоноподобного Пептида-1 (Гпп-1) В Комбинации С Метформином При Сахарном Диабете 2 Типа. Pharmacoeconomics: Theory and Practice, 5(1), 84–84. https://doi.org/10.30809/phe.1.2017.21
Kumar, M., Kaushik, D., Kumar, A., Gupta, P., Proestos, C., Oz, E., Orhan, E., Kaur, J., Khan, M. R., Elobeid, T., Bordiga, M., & Oz, F. (2023). Green synthesis of copper nanoparticles from Nigella sativa seed extract and evaluation of their antibacterial and antiobesity activity. International Journal of Food Science and Technology, 58(6), 2883–2892. https://doi.org/10.1111/ijfs.16359
Longdong, I. A., Tooy, D., Rantung, R. A., Ransun, K., Pinatik, H., & Saroinsong, D. (2025). Karakteristik Pengeringan Jahe Merah ( Zingiber Officinale Var . Rubrum ) Menggunakan Alat Pengering Tipe Kubah. Karakteristik Pengeringan Jahe Merah (Zingiber Officinale Var. Rubrum) Menggunakan Alat Pengering Tipe Kubah, 16, 0–7. https://doi.org/10.21107/agrointek.v15i1.7661
Marslin, G., Siram, K., Maqbool, Q., Selvakesavan, R. K., Kruszka, D., Kachlicki, P., & Franklin, G. (2018). Secondary metabolites in the green synthesis of metallic nanoparticles. Materials, 11(6), 1–25. https://doi.org/10.3390/ma11060940
Mita, F., Jumarni, A., Wati, R., Patimah, A., & Rahman, D. Y. (2024). Perkembangan Penerapan Nanoteknologi di Bidang Pelapisan (Coating) Development of Applied Nanotechnology in Coating. Jurnal Penelitian Fisika Dan Terapannya (Jupiter), 5(2), 1–29. https://doi.org/10.31851/jupiter.v5i2.33738
Miu, B. A., & Dinischiotu, A. (2022). New Green Approaches in Nanoparticles Synthesis: An Overview. Molecules, 27(19). https://doi.org/10.3390/molecules27196472
Mourdikoudis, S., Pallares, R. M., & Thanh, N. T. K. (2018). Characterization techniques for nanoparticles: Comparison and complementarity upon studying nanoparticle properties. Nanoscale, 10(27), 12871–12934. https://doi.org/10.1039/c8nr02278j
Ningsih, A. W., Jihan Fahiroh Nur Arifin, Retno Wulan Devitri, Rusdiana Tri Septiarini, Elvira Silvany Zahara, Vira Maulidya, Yasmine Eka Maulidya, Elly Eka Rahmawati, Zakkiya Sabila, Zahratul Humaidah, & Ivan Charles S.Klau. (2025). Tinjauan Literatur: Efektivitas Maserasi sebagai Metode Ekstraksi Fitokimia. OBAT: Jurnal Riset Ilmu Farmasi Dan Kesehatan, 3(6), 228–242. https://doi.org/10.61132/obat.v3i6.1927
Pourmadadi, M., Holghoomi, R., Shamsabadipour, A., Maleki-baladi, R., Rahdar, A., & Pandey, S. (2024). Copper nanoparticles from chemical, physical, and green synthesis to medicinal application: A review. Plant Nano Biology, 8(December 2023), 100070. https://doi.org/10.1016/j.plana.2024.100070
Qomariyah, A., Wulandari, E. Y., & Najib, A. (2025). Sintesis dan Karakterisasi Nanopartikel CuO-Kitosan serta Uji Antibakteri terhadap Streptococcus pneumoniae. Indonesian Journal of Chemical Research, 10(1). https://doi.org/10.20885/ijcr.vol10.iss1.art2
Rahayu, N., & Ardigurnita, F. (2021). Potential of Katuk Leaves As Lowering Fat Levels in Poultry. Jurnal Ilmu Pertanian Dan Peternakan, 9(2), 136–139. https://doi.org/https://doi.org/10.31949/agrivet.v9i2.1697
Ramadhan, H., Andina, L., Yuliana, K. A., Baidah, D., & Lestari, N. P. (2020). Phytochemical screening and rendemen comparison of 96% ethanol extract of terap (Artocarpus odoratissimus Blanco) leaf, flesh and peel / Skrining fitokimia dan perbandingan rendemen ekstrak etanol 96% daun, buah, dan kulit buah terap (Artocarpus odoratiss. Jurnal Ilmiah Farmako Bahari, vol 11, 103–112. https://journal.uniga.ac.id/index.php/JFB
Salim, R., Taslim, T., Selonni, F., Verawaty, V., & Dewi, I. P. (2025). Decoction of Cocos nucifera Linn. : Antioxidant Activity, Total Phenolics, and Flavonoids Contents. Indonesian Journal of Pharmaceutical Science and Technology, 12(2), 129–136. https://doi.org/10.24198/ijpst.v12i2.45058
Selvam, M. S., Tresina, P. S., Mohan, V. R., Rani, S. A., & Jeeva, S. (2025). Eco-friendly fabrication and characterization of copper nanoparticles via Cymodocea serrulata (R.Br.) Asch. & Magnus extract: Evaluation of antioxidant and antibacterial activities. Next Materials, 9(October 2024), 100963. https://doi.org/10.1016/j.nxmate.2025.100963
Syahadat, A., & Siregar, N. (2020). Phytochemical Screening of Katuk Leaves (Sauropus androgynus) as a Lactation Promoter. Jurnal Kesehatan Ilmiah Indonesia, 5(1), 85–89.
Villagrán, Z., Anaya-Esparza, L. M., Velázquez-Carriles, C. A., Silva-Jara, J. M., Ruvalcaba-Gómez, J. M., Aurora-Vigo, E. F., Rodríguez-Lafitte, E., Rodríguez-Barajas, N., Balderas-León, I., & Martínez-Esquivias, F. (2024). Plant-Based Extracts as Reducing, Capping, and Stabilizing Agents for the Green Synthesis of Inorganic Nanoparticles. Resources, 13(6). https://doi.org/10.3390/resources13060070
Widwiastuti, H., Malang, P. K., & Ukuran, P. (2022). Pengaruh ukuran simplisia dan lama kontak pada ekstraksi senyawa aktif simplisia kayu jawa ( lannea coromandelica ) menggunakan metode maserasi effect of simplisia size and contact time on the extraction of active compounds of kayu jawa simplisia ( lannea. Effect of simplisia size and contact time on the extraction of active compounds of kayu jawa simplisia (lannea coromandelica) using the maceration method, 19, 86–90.
wina safutri, dewi damayanti abdulkarim, merly fevinia. (2015). Abstrak Skrining fitokimia merupakan metode yang digunakan untuk mempelajari komponen contained in samples , namely their chemical structure , biosynthesis , natural compositions of various types of plants . Several types of plants used by people in turme. Farmasi, 23–27. http://journal.aisyahuniversity.ac.id/index.php/JFA%0ASKRINING
Yusuf, A., Almotairy, A. R. Z., Henidi, H., Alshehri, O. Y., & Aldughaim, M. S. (2023). Nanoparticles as Drug Delivery Systems: A Review of the Implication of Nanoparticles’ Physicochemical Properties on Responses in Biological Systems. Polymers, 15(7), 1–26. https://doi.org/10.3390/polym15071596
Zambare, P., Survase, A., & Kanase, S. (2022). Green Synthesis of Copper Nanoparticles Using Leaf Extract of Ocimum sanctum and its Antimicrobial Activity. International Journal of Pharmaceutical Investigation, 13(1), 106–112. https://doi.org/10.5530/223097131692
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2026-08-03
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