Studi Literatur: Potensi Ekstrak Daun Kelor sebagai Terapi Topikal Luka Bakar
DOI:
https://doi.org/10.29313/bcsp.v6i2.25323Keywords:
Daun kelor, Luka bakar, Sediaan topikalAbstract
Abstract. Burn injuries are a type of tissue damage that require appropriate treatment to accelerate the healing process. Moringa leaves (Moringa oleifera Lam.) contain various bioactive compounds that may contribute to tissue regeneration during wound healing. Moringa oleifera Lam. (moringa) leaf is widely reported to contain flavonoids, tannins, saponins, alkaloids, and phenolic compounds with antioxidant, antimicrobial, and anti-inflammatory activity that support tissue regeneration. This study aims to map and synthesize scientific evidence on the potential of moringa leaf extract in various pharmaceutical dosage forms for burn wound therapy. A narrative literature review method was used, tracing national and international journal articles published between 2016 and 2026. The results show that moringa leaf extract has been formulated into ointments, creams, gels/hydrogels, and biocellulose patches, with effective concentrations generally ranging from 2.5% to 15%, and that its healing activity is associated with increased VEGF expression, TGF-β1 modulation, collagen deposition, and suppression of the inflammatory phase. It is concluded that moringa leaf extract shows strong and consistent potential as a natural active ingredient for burn wound care and merits further clinical development.
Abstrak. Luka bakar merupakan jenis kerusakan jaringan yang harus ditangani secara tepat guna mempercepat proses penyembuhan. Daun kelor (Moringa oleifera Lam.) mengandung beberapa senyawa bioaktif yang dapat mempengaruhi proses regenerasi jaringan pada luka. Daun kelor (Moringa oleifera Lam.) dilaporkan secara luas mengandung flavonoid, tanin, saponin, alkaloid, dan senyawa fenolik dengan aktivitas antioksidan, antimikroba, dan anti-inflamasi yang mendukung regenerasi jaringan. Penelitian ini bertujuan memetakan dan mensintesis bukti ilmiah mengenai potensi ekstrak daun kelor dalam berbagai bentuk sediaan farmasi untuk terapi luka bakar. Metode yang digunakan adalah studi literatur naratif dengan menelusuri artikel jurnal nasional dan internasional terbitan tahun 2016-2026. Hasil kajian menunjukkan bahwa ekstrak daun kelor telah diformulasikan ke dalam salep, krim, gel/hidrogel, dan patch bioselulosa, dengan konsentrasi efektif umumnya berkisar 2,5% hingga 15%, dan aktivitas penyembuhannya berkaitan dengan peningkatan ekspresi VEGF, modulasi TGF-β1, deposisi kolagen, serta penekanan fase inflamasi. Disimpulkan bahwa ekstrak daun kelor memiliki potensi yang kuat dan konsisten sebagai bahan aktif alami untuk perawatan luka bakar dan layak dikembangkan lebih lanjut secara klinis.
References
Al-Ghanayem, A. A., Alhussaini, M. S., Asad, M., & Joseph, B. (2022). Moringa oleifera Leaf Extract Promotes Healing of Infected Wounds in Diabetic Rats: Evidence of Antimicrobial, Antioxidant and Proliferative Properties. Pharmaceuticals, 15(5). https://doi.org/10.3390/ph15050528
Amalia, E. W., Chiuman, L., & Fachrial, E. (2025). Therapeutic Potential of Moringa oleifera Leaf Cream in Promoting Wound Healing Through VEGF and Collagen Modulation in Burn Injury. 247–258. https://doi.org/10.2991/978-94-6463-962-9_25
Djuwarno, E. N., Hiola, F., & Isa, I. (2021). Formulation of emulgel preparation of moringa leaf extract (Moringa oleifera Lam) and antioxidant activity test using DPPH method. Ijpe, 1(1), 2775–3670. https://doi.org/10.22487/.ijpe.vlil.99457
Fitri, Z. A., Ahmadi, F., Islam, M. A., Ponnampalam, E. N., Dunshea, F. R., & Suleria, H. A. R. (2025). A Systematic Review of Extraction Methods, Phytochemicals, and Food Applications of Moringa oleifera Leaves Using PRISMA Methodology. Food Science and Nutrition, 13(4), 1–16. https://doi.org/10.1002/fsn3.70138
Mohd Reza Bahlia, M. B. R. (2025). Luka Bakar.
Monica, A. B. (2024). Pemanfaatan ekstrak daun kelor (Moringa oleifera L.) dalam minyak zaitun (Olea europea L.) Sebagai obat penyembuh luka bakar. Maliki Interdisciplinary Journal, 2(4), 42–46. http://urj.uin-malang.ac.id/index.php/mij/article/view/4617
Muzammil, S., Neves Cruz, J., Mumtaz, R., Rasul, I., Hayat, S., Khan, M. A., Khan, A. M., Ijaz, M. U., Lima, R. R., & Zubair, M. (2023). Effects of Drying Temperature and Solvents on In Vitro Diabetic Wound Healing Potential of Moringa oleifera Leaf Extracts. Molecules, 28(2). https://doi.org/10.3390/molecules28020710
Sahu, H., Satapathy, T., Chandrakar, S., Gupta, P. P., Sahu, P., & Sahu, A. (2024). CONTAINING HYDROALCOHOLIC EXTRACT DERIVED. 12(4), 44–53.
Shady, N. H., Mostafa, N. M., Fayez, S., Abdel-Rahman, I. M., Maher, S. A., Zayed, A., Saber, E. A., Khowdiary, M. M., Elrehany, M. A., Alzubaidi, M. A., Altemani, F. H., Shawky, A. M., & Abdelmohsen, U. R. (2022). Mechanistic Wound Healing and Antioxidant Potential of Moringa oleifera Seeds Extract Supported by Metabolic Profiling, In Silico Network Design, Molecular Docking, and In Vivo Studies. Antioxidants, 11(9). https://doi.org/10.3390/antiox11091743
Susanti Nitya Nurul; Nurani, Ai Selvia; Karimah, Ira Siti; Wulandari, Nita; Dani, Rendi Saepul, S. F. (2024). Formulasi Sediaan Patch Bioselulosa Ekstrak Daun Kelor (Moringa oleifera) untuk Pengobatan Luka Bakar: Formulation of Moringa Leaf (Moringa oleifera) Extract Biocellulose Patch for Burns Treatment. Jurnal Sains Dan Kesehatan, (Vol. 6 No. 1 (2024): J. Sains Kes.), 1–9. https://jsk.jurnalfamul.com/index.php/jsk/article/view/2185/597
Triastuti, Y., Putri, N. N., & Hasya, M. N. (2023). Test of the Effectiveness of Moringa Oleifera Leaf Extract Cream on the Healing Process of Cut Wounds on the Skin Surface of Male Wistar Rats (Rattus Norvegicus). Jurnal Eduhealt, 14(04), 2023. http://ejournal.seaninstitute.or.id/index.php/healt
Wahyudi, W., & Agustina, H. (2018). Sediaan Salep Ekstrak Daun Kelor (Moringa Oleifera Lam) Sebagai Penyembuhan Luka Bakar Topikal Pada Kelinci (Oryctolagus Cuniculus). Jurnal Farmasimed (Jfm), 1(1), 21–24. https://doi.org/10.35451/jfm.v1i1.91
