Efektivitas Antibiotik Pasien Rawat Inap Pneumonia Komunitas di RSUD Welas Asih
DOI:
https://doi.org/10.29313/bcsp.v6i2.24735Keywords:
Antibiotik, Pneumonia Komunitas, Outcome klinisAbstract
Abstract. Community-acquired pneumonia (CAP) remains a global health challenge due to its high mortality rate, making appropriate antibiotic selection essential to prevent treatment failure and the threat of resistance. This study aimed to analyze the effectiveness of various antibiotic regimens on clinical outcomes, including leukocyte count, body temperature, and respiratory rate. This analytical observational study with a cross-sectional design involved 123 inpatients at RSUD Welas Asih during the 2025 period, selected using a total sampling technique. Secondary data were obtained from medical records and analyzed both descriptively and statistically using the Wilcoxon test. The results showed that the majority of subjects were male (50.4%) and elderly (44.7%), with levofloxacin monotherapy (55%) and ceftriaxone (16%) being the predominant regimens used. Statistically, both antibiotics significantly reduced leukocyte levels (p<0.05), although temperature and respiratory rate parameters did not show similar significance, yet still achieved clinical stability by the third day. In conclusion, levofloxacin and ceftriaxone were the statistically most effective regimens, with further research using a larger sample size recommended.
Abstrak. Pneumonia komunitas (community-acquired pneumonia) menjadi tantangan kesehatan global karena angka mortalitas yang tinggi, sehingga pemilihan antibiotik yang tepat sangat penting untuk mencegah kegagalan terapi dan ancaman resistensi. Penelitian ini bertujuan menganalisis efektivitas berbagai regimen antibiotik terhadap outcome klinis yang meliputi kadar leukosit, suhu tubuh, dan laju pernapasan. Studi observasional analitik dengan desain cross-sectional ini melibatkan 123 pasien rawat inap di RSUD Welas Asih periode 2025 yang diambil menggunakan teknik total sampling. Data sekunder diperoleh dari rekam medis dan diolah secara deskriptif serta statistik menggunakan uji Wilcoxon. Hasil menunjukkan mayoritas subjek adalah laki-laki (50,4%) dan lansia (44,7%), dengan penggunaan dominan monoterapi levofloksasin (55%) dan seftriakson (16%). Secara statistik, kedua antibiotik tersebut signifikan menurunkan kadar leukosit (p<0,05), meskipun parameter suhu dan napas tidak menunjukkan signifikansi serupa namun tetap mencapai stabilitas klinis pada hari ketiga. Kesimpulannya, levofloksasin dan seftriakson adalah regimen paling efektif secara statistik, dengan saran penelitian lanjutan menggunakan jumlah sampel yang lebih besar.
References
Dewan Jaminan Sosial Nasional BPJS Kesehatan. (2022). 202212131425Buku Statistik JKN 2016-2021.
DiPiro, J. T., Yee, G. C., Haines, S. T., Nolin, T. D., Ellingrod, V. L., & L. Michael Posey. (2023). DIPIRO’S PHARMACOTHERAPY A PAT H O P HYS I O LO G I C A P P R OAC H 12TH EDITION.
Fachri, M., Hatta, M., Zakia, D., Akaputra, R., Wahab, A., Azhar, A., & Junita, A. R. (2025). Comparison of Length of Treatment and Comorbidities in Older and Adult Hospitalized Patients with Bacterial Community-Acquired Pneumonia. Eurasian Journal of Medicine, 57(3). https://doi.org/10.5152/eurasianjmed.2025.25910
Fahlevi, R., Phill, P., Papilaya, E., Alfa, W., Putu, S., Pradnyani, E., Al-Faida, N., Fatma, A., Ayatullah, D., Arif, H., Asruria, R., & Fajriah, S. (2022). DASAR BIOSTATISTIKA UNTUK PENELITI PENULIS. www.getpress.co.id
Faradhila, A., Indawati, I., & Nurhaini, R. (2023). Evaluasi Penggunaan Antibiotik Yang Rasional Pada Pasien Pneumonia Rawat Inap Di RS X Kota Cirebon. In Jurnal Ilmu Farmasi (Vol. 14, Number 2).
Farras Aziz, F., Suryadinata, H., & Wahyudi, K. (2020). POLA BAKTERI PASIEN RAwAT INAP PNEumONIA KOmuNITAS DEwASA RumAH SAKIT HASAN SADIKIN BANDuNG TAHuN 2018. In Indonesia Journal Chest | (Vol. 7, Number 2).
Fauziyah, R. N. (2019). Sampling dan Besar Sampel Bidang Kesehatan Masyarakat dan Klinis Penerbit Politeknik Kesehatan Kemenkes Bandung.
He, L., Zhou, C., Zhao, S., Weng, H., & Yang, G. (2015). Once-daily, oral levofloxacin monotherapy for low-risk neutropenic fever in cancer patients: A pilot study in China. Anti-Cancer Drugs, 26(3), 359–362. https://doi.org/10.1097/CAD.0000000000000187
Herdika, Y., & Rohani Lasmaria. (2023). Antibiotic Management in Bacterial Pneumonia: A Narrative Literature Review. Bioscientia Medicina : Journal of Biomedicine and Translational Research, 8(3), 4072–4081. https://doi.org/10.37275/bsm.v8i3.934
Hikmah, N., Andayani, T. M., & Puspitasari, I. (2024). Comparison of effectiveness and safety between ceftriaxone/azithromycin and levofloxacin in hospitalized CAP patients: a review. Majalah Farmaseutik, 20(3), 382. https://doi.org/10.22146/farmaseutik.v20i3.94147
Hikmah, N., & Sholih, M. G. (2025). Effectiveness of β-lactam and Macrolide Antibiotic Combination in Patients with Community-Acquired Pneumonia: A Review. Jurnal Pijar Mipa, 20(4), 776–782. https://doi.org/10.29303/jpm.v20i4.8163
H. Ticona, J., M. Zaccone, V., & M. McFarlane, I. (2020). Community-Acquired Pneumonia: A Focused Review. American Journal of Medical Case Reports, 9(1), 45–52. https://doi.org/10.12691/ajmcr-9-1-12
Kemenkes RI. (2023). KEPUTUSAN MENTERI KESEHATAN REPUBLIK INDONESIA.
Metlay, J. P., Waterer, G. W., Long, A. C., Anzueto, A., Brozek, J., Crothers, K., Cooley, L. A., Dean, N. C., Fine, M. J., Flanders, S. A., Griffin, M. R., Metersky, M. L., Musher, D. M., Restrepo, M. I., & Whitney, C. G. (2019). Diagnosis and treatment of adults with community-acquired pneumonia. American Journal of Respiratory and Critical Care Medicine, 200(7), E45–E67. https://doi.org/10.1164/rccm.201908-1581ST
Nguyen, Y., Corre, F., Honsel, V., Curac, S., Zarrouk, V., Fantin, B., & Galy, A. (2020). Applicability of the CURB-65 pneumonia severity score for outpatient treatment of COVID-19. In Journal of Infection (Vol. 81, Number 3, pp. e96–e98). W.B. Saunders Ltd. https://doi.org/10.1016/j.jinf.2020.05.049
Perhimpunan Dokter Paru Indonesia. (2022). Perhimpunan Dokter Paru Indonesia (PDPI) Tahun 2022 PNEUMONIA KOMUNITAS.
Prof. Dr. Sugiyono. (2023). METODE PENELITIAN KUANTITATIF, KUALITATIF, DAN R&D (Prof. Dr. Sugiyono, Ed.; Vol. 2).
Rahardjoputro, R., Rahma Widyaningrum, N., & Ernawati. (2024). EFEKTIVITAS ANTIBIOTIK EMPIRIS UNTUK PASIEN PNEUMONIA KOMUNITAS DEWASA DI RS X SURAKARTA. In Jurnal Riset Ilmiah (Vol. 3, Number 2).
Raising, R., Rosalina, V., Studi, P. S., Bhakti Husada Mulia Madiun, S., & Studi DIII Farmasi, P. (2017). EFEKTIFITAS ANTIBIOTIK TERHADAP PERUBAHAN SUHU DAN LEUKOSIT PADA PASIEN PNEUMONIA.
Reviono, Sp. (2017). PNEUMONIA: Adakah tempat untuk pemberian antiinflamasi ?
Rifka Agustianti, P., Nussifera, L., Angelianawati, L., Meliana, I., Alfiani Sidik, E., Nurlaila, Q., Simarmata, N., Sophan Himawan, I., Pawan, E., Ikhram, F., Dwi Andriani, A., & Rai Hardika Editor Ni Putu Gatriyani Nanny Mayasari, I. (2022). METODE PENELITIAN KUANTITATIF DAN KUALITATIF TOHAR MEDIA. https://toharmedia.co.id
Rumende, C. M., Chen, L. K., Karuniawati, A., Bratanata, J., Falasiva, R., Sitorus, T. P., & Susanto, E. C. (2019). Hubungan antara Ketepatan Pemberian Antibiotik Berdasarkan Alur Gyssens dengan Perbaikan Klinis Pasien pada Pneumonia Komunitas Correlation between Proper Antibiotics Administration to Community Acquired Pneumonia Patients Based on Alur Gyssens with Clinical Response. In Jurnal Penyakit Dalam Indonesia | (Vol. 6, Number 2).
Ryla, C., Rk, N., & Mardina, V. (2019). PEMERIKSAAN JUMLAH LEUKOSIT, LAJU ENDAP DARAH DAN BAKTERI TAHAN ASAM (BTA) PADA PASIEN PENYAKIT TUBERCULOSIS PARU DI RSUD LANGSA EVALUATION OF LEUKOSIT, BLOOD RATE AND BACTERIAL ACID (BTA) IN PATIENTS OF LUNG TUBERCULOSIS DISEASE AT LANGSA HOSPITAL. In Biologica Samudra (Vol. 1, Number 2).
Syah, F. Z. N., Rahem, A., Purnamayanti, A., & Karunia, R. I. (2022). EFEKTIVITAS ANTIBIOTIK PADA PASIEN PNEUMONIA COVID-19 : STUDI OBSERVASIONAL. Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi Dan Kesehatan, 7(2), 241–250. https://doi.org/10.36387/jiis.v7i2.878
Tambun, S. H., Puspitasari, I., & Laksanawati, I. S. (2019). Evaluasi Luaran Klinis Terapi Antibiotik pada Pasien Community Acquired Pneumonia Anak Rawat Inap. JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice), 9(3), 213. https://doi.org/10.22146/jmpf.47915
Tania Tnesi, M., Permata, A., Gadis Aprilianti, R., & Choirunniswah, J. (2023). Evaluasi Penggunaan Antibiotik pada Pasien Pneumonia di Rumah Sakit X Kota Malang. Indonesian Journal of Pharmaceutical Education, 3(3). https://doi.org/10.37311/ijpe.v3i3.22100
Wheatley I. (2018). 180912-Respiratory-rate-5-using-this-vital-sign-to-detect-deterioration.
