Formulasi Sediaan Patch Mengandung Ekstrak Etanol Daun Sembung (Blumea balsamifera L.)
DOI:
https://doi.org/10.29313/bcsp.v6i2.24679Keywords:
Daun sembung, Flavonoid, Patch, Penutup lukaAbstract
Abstract. A laceration is skin damage caused by sharp-object trauma and may lead to bleeding and infection. Sembung leaves (Blumea balsamifera L.) contain flavonoids with potential wound-healing activity. This study aimed to determine the optimal formulation of a patch containing ethanol extract of Sembung leaves and to evaluate its in vivo wound-healing efficacy. Patch optimization was performed using a trial-and-error method by varying HPMC and PVP concentrations. Formula 3, containing 2.25% HPMC and 0.75% PVP, was selected as the optimal base. The patch was round, blackish-green, homogeneous, had a characteristic extract aroma, moisture content of the patch (7.26% ± 0.2), weight uniformity (0.02 g ± 0.00), thickness (0.3 mm ± 0), fold resistance >200 times, and pH (6.37 ± 0.01). Furthermore, the results of the 5% patch formula (F3C) showed the best efficacy in wound healing on the.
Abstrak. Luka sayat merupakan kondisi terjadinya kerusakan pada jaringan kulit yang disebabkan oleh trauma benda tajam seperti pisau ataupun benda tajam lainnya, sehingga berisiko mengalami perdarahan dan infeksi. Daun sembung (Blume balsamifera L.) mengandung berbagai senyawa kimia aktif, salah satunya yaitu flavonoid yang memiliki potensi untuk mempercepat waktu penyembuhan luka sayat. Tujuan penelitian ini adalah untuk mendapatkan formulasi terbaik sediaan patch yang mengandung ekstrak etanol daun sembung yang diperoleh dari hasil evaluasi dan hasil efektivitas penutupan luka secara in vivo. Optimasi formula sediaan patch dibuat berdasarkan variasi konsentrasi HPMC dan PVP sebagai polimer. Formula optimal sediaan patch didapatkan pada formula 3 dengan kombinasi HPMC 2,25% dan PVP 0,75% menghasilkan patch yang memenuhi persyaratan evaluasi yaitu berbentuk lembaran persegi panjang, berwarna hijau kehitaman, beraroma khas ekstrak, homogen, kadar air patch (7,26% ± 0,2), keseragaman bobot (0,02 g ± 0,00), ketebalan (0,3 mm ± 0), ketahanan lipatan >200 kali dan pH (6,37 ± 0,01). Kemudian, hasil efektivitas formula patch 5% (F3C) menunjukkan hasil terbaik dengan penyembuhan luka pada hari ke- 12.
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