Studi Literatur Nanostructured Lipid Carriers (NLC) untuk Pengobatan Jerawat
Abstract
Abstract. Acne is a chronic inflammatory disorder of the pilosebaceous unit. The first-line treatment for acne is topical medications made from synthetic compounds. However, synthetic compounds usually cause skin irritation, dryness and itching. To overcome these limitations, it can be done by encapsulating in lipid-based nano-delivery systems such as Nanostructured Lipid Carriers (NLC). This study aims to assess the formulation and characteristics of NLC containing anti-acne compounds. The method used was Systematic Literature Review (SLR) with articles taken from various reputable databases. The results of the literature review showed that NLC formulations containing anti-acne compounds were made with a combination of solid lipids, liquid lipids, and non-ionic surfactants. Characterization showed that the particle size of the NLCs was in the range of 158.4 to 762 nm, the polydispersity index (PDI) was less than 0.5, the zeta potential was in the range of -28.3 to -53.1 mV, and the sorption efficiency was in the range of 91.16% to 98.58%. Based on these results, NLCs containing anti-acne compounds show good physical stability and have the potential to increase the effectiveness of anti-acne compounds for topical application.
Abstrak. Jerawat merupakan kelainan peradangan kronis pada unit pilosebaseus. Pengobatan lini pertama untuk jerawat adalah obat topikal yang terbuat dari senyawa sintetis. Namun senyawa sintesis biasanya menyebabkan iritasi kulit, kekeringan dan gatal. Untuk mengatasi keterbatasan ini, dapat dilakukan dengan mengenkapsulasi dalam sistem penghantaran nano berbasis lipid seperti Nanostructured Lipid Carriers (NLC). Penelitian ini bertujuan untuk mengkaji formulasi dan karakteristik NLC yang mengandung senyawa antijerawat. Metode yang digunakan yaitu Systematic Literature Review (SLR) dengan artikel yang diambil dari berbagai basis data bereputasi. Hasil kajian literatur menunjukkan bahwa formulasi NLC yang mengandung senyawa antijerawat dibuat dengan kombinasi lipid padat, lipid cair, dan surfaktan non-ionik. Karakterisasi menunjukkan ukuran partikel NLC berada dalam rentang 158,4 hingga 762 nm, indeks polidispersitas (PDI) kurang dari 0,5, zeta potensial dalam rentang -28,3 hingga -53,1 mV, dan efisiensi penjerapan dalam rentang 91,16% hingga 98,58%. Berdasarkan hasil tersebut, NLC yang mengandung senyawa antijerawat menunjukkan stabilitas fisik yang baik dan berpotensi meningkatkan efektivitas senyawa antijerawat untuk aplikasi topikal.
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