Studi Literatur Potensi Tanaman Bandotan (Ageratum conyzoides L.) sebagai Antidiabetes
Keywords:
Diabetes mellitus, antidiabetes, Ageratum conyzoides L.
Abstract
Diabetes mellitus (DM) is a metabolic disease characterized by hyperglycemia (high blood glucose levels), which can occur due to insulin deficiency, insulin resistance, or both. The utilization of plants as traditional medicine or as an alternative treatment for diabetes is increasing over time, and also as an alternative approach that is easy to implement. Bandotan or Babadotan (Ageratum conyzoides L.) is one of the plants from the Asteraceae tribe that has long been used in the treatment of diabetes. The purpose of this study was to determine the potential of antidiabetic activity in bandotan plants and secondary metabolite compounds that are thought to have potential as antidiabetics. The research was conducted using the Systematic Literature Review method by collecting data from 17 articles and obtained from database search engines like Google scholar, Science Direct, SpringerLink, and PubMed. Data used from scientific articles are in the form of plant parts used, plant sources, extraction methods, types of solvents, test animals, test methods, effective doses of extracts and the amount of reduction in blood glucose levels. The results of in vivo and in vitro tests proved that bandotan plant parts such as flowers, leaves, stems and roots, can reduce blood glucose levels with various mechanisms of action. Bandotan plants (Ageratum conyzoides L.) contain a class of compounds, including flavonoids, alkaloids, tannins and saponins which are thought to have potential as antidiabetics.
References
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Agbafor, K. N., Onuohah, S. C., Ominyi, M. C., Orinya, O. F., & Alum. (2015). Antidiabetic, Hypolipidemic and Antiathrogenic Properties of Leaf Extracts of Ageratum conyzoides in Streptozotocin-Induced diabetic rats. Int.J.Curr.Microbiol.App.Sci, 4(11), 816–824. http://www.ijcmas.com
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Ojewale, A., Mada, S., Oyebadejo, S., Afodun, A., Aladeyelu, O., & Kolawole, B. (2020). Cardioprotective Activities of Ethanolic Extract Root of Ageratum conyzoides on Alloxan-Induced Cardiotoxicity in Diabetic Rats. BioMed Research International, 2020. https://doi.org/10.1155/2020/3189672
Olubomehin, O. O., Adeyemi, O. O., & Awokoya, K. N. (2016). Preliminary investigation into the alpha-amylase inhibitory activities of Ageratum conyzoides (Linn.) leaf extracts. Journal of Chemical Society of Nigeria, 41(2), 73–76.
Onsiyor, E. J.-B., Akaffou, N. A., Zahoui, O. S., & Traore, F. (2019). Effets antidiabétiques de l’extrait aqueux de Ageratum conyzoïdes (Astéraceae) chez les rats rendus diabétiques par pancréatectomie partielle et évaluation de leurs paramètres hématologiques. International Journal of Biological and Chemical Sciences, 13(3), 1621. https://doi.org/10.4314/ijbcs.v13i3.33
Oso, B. J., & Olaoye, I. F. (2020). Comparative in vitro studies of antiglycemic potentials and molecular docking of Ageratum conyzoides L. and Phyllanthus amarus L. methanolic extracts. SN Applied Sciences, 2(4), 1–13. https://doi.org/10.1007/s42452-020-2275-5
Parmar, K., Aggarwal, G., & Sharma, U. (2024). α-Glucosidase Inhibiting Chromene Derivatives from Ageratum conyzoides L. Essential Oil Extracted via NADES-Assisted Hydrodistillation. Chemistry and Biodiversity, 202401324. https://doi.org/10.1002/cbdv.202401324
Pay, C., Watuguly, T., & Wael, S. (2022). Potensi Ekstrak Daun Bandotan (Ageratum conyzoides L) Sebagai Obat Diabetes Melitus. Jurnal Biologi Pendidikan Dan Terapan, 9(1), 89–99.
PERKENI. (2021). Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia 2021. Global Initiative for Asthma, 46. www.ginasthma.org.
Petersmann, A., Nauck, M., Müller-Wieland, D., Kerner, W., Müller, U. A., Landgraf, R., Freckmann, G., & Heinemann, L. (2018). Definition, classification and diagnostics of diabetes mellitus. Journal of Laboratory Medicine, 42(3), 73–79. https://doi.org/10.1515/labmed-2018-0016
Rafe, M. R. (2017). A review of five traditionally used anti-diabetic plants of Bangladesh and their pharmacological activities. Asian Pacific Journal of Tropical Medicine, 10(10), 933–939. https://doi.org/10.1016/j.apjtm.2017.09.002
Sida, A., Kasmawati, H., Idrus, L., & Ruslin. (2023). Lansau : Jurnal Ilmu Kefarmasian ( LJIK ) Potensi Bandotan (Ageratum conyzoides Linn.) sebagai Pencegah. 1(2), 89–100. https://doi.org/10.33772/lansau.v1i2.12
World Health Organization. (n.d.). Diabetes. Retrieved November 15, 2023, from https://www.who.int/health-topics/diabetes#tab=tab_1
Adelakun, S. A., Ogunlade, B., Omotoso, O. D., & Oyewo, O. O. (2018). Response of crude leaf extract of ageratum conyzoides on hormonal and biochemical assay in streptozotocin induced diabetic male wistar rats. Indian Journal of Physiology and Pharmacology, 62(4), 413–423.
Agbafor, K. N., Onuohah, S. C., Ominyi, M. C., Orinya, O. F., & Alum. (2015). Antidiabetic, Hypolipidemic and Antiathrogenic Properties of Leaf Extracts of Ageratum conyzoides in Streptozotocin-Induced diabetic rats. Int.J.Curr.Microbiol.App.Sci, 4(11), 816–824. http://www.ijcmas.com
Atawodi, S. E., Adepoju, O. A., & Nzelibe, H. C. (2017). Antihyperglycaemic and hypolipidemic effect of methanol extracts of ageratum conyzoides L (Asteraceae) in normal and diabetic rats. Tropical Journal of Pharmaceutical Research, 16(5), 989–996. https://doi.org/10.4314/tjpr.v16i5.4
Behl, T., Gupta, A., Albratty, M., Najmi, A., Meraya, A. M., Alhazmi, H. A., Anwer, M. K., Bhatia, S., & Bungau, S. G. (2022). Alkaloidal Phytoconstituents for Diabetes Management: Exploring the Unrevealed Potential. Molecules, 27(18). https://doi.org/10.3390/molecules27185851
Choudhary, N., Khatik, G. L., & Suttee, A. (2021). The Possible Role of Saponin in Type-II Diabetes- A Review. Current Diabetes Reviews, 17(2), 107–121. https://doi.org/10.2174/1573399816666200516173829
Doh, K. S., Koffi, N., & Aké, C. B. (2013). Effect of aqueous extract of Ageratum conyzoides leaves on the glycaemia of rabbits. The Pharma Innovation, 2(8, Part A), 1–8.
Elsayed, N. A., Aleppo, G., Aroda, V. R., Bannuru, R. R., Brown, F. M., Bruemmer, D., Collins, B. S., Hilliard, M. E., Isaacs, D., Johnson, E. L., Kahan, S., Khunti, K., Kosiborod, M., Leon, J., Lyons, S. K., Murdock, L., Perry, M. Lou, Prahalad, P., Pratley, R. E., … Gabbay, R. A. (2023). 2. Classification and Diagnosis of Diabetes: Standards of Care in Diabetes—2023. Diabetes Care. https://doi.org/10.2337/dc23-S002
Hardianto, D. (2021). Telaah Komprehensif Diabetes Melitus: Klasifikasi, Gejala, Diagnosis, Pencegahan, Dan Pengobatan. Jurnal Bioteknologi & Biosains Indonesia (JBBI), 7(2), 304–317. https://doi.org/10.29122/jbbi.v7i2.4209
Ikhwan, M., Des, M., & Chatri, M. (2021). Inventory of Medicinal Plants that have the Potential to Treat Diabetes Mellitus in Sijunjung District. Jurnal Serambi Biologi, 6(2), 1–8. https://serambibiologi.ppj.unp.ac.id/index.php/srmb/article/view/6
International Diabetes Federation. (2021). Global Fact Sheet-Diabetes around the world. https://diabetesatlas.org/idfawp/resource-files/2021/11/IDFDA10-global-fact-sheet.pdf
Istifanus, G., Luka, C. D., & Johnson, T. O. (2022). Effect of Aqueous Extracts of Flower, Leaf, Stem and Root of Ageratum conyzoides L on Glucose, Lipid Profile and Liver Markers on Streptozocin Induced Diabetic Rats. South Asian Research Journal of Natural Products, 5(4), 31–39. http://files/377/Istifanus et al. - 2022 - Effect of Aqueous Extracts of Flower, Leaf, Stem a.pdf
Kazeem, M. I., Ogenkelu, O., Ayeleso, A. O., & Mukwevho, E. (2018). Screening of Different Extracts of Ageratum Conyzoides for Inhibition of Diabetes-Related Enzymes. In Bioactive Compounds of Medicinal Plants (1st ed., pp. 234–249).
Nyunai, N., Abdennebi, E., Bickii, J., & Manguelle-Dicoum, M. A. (2015). Subacute antidiabetic properties of Ageratum conyzoides leaves in diabetic rats SUBACUTE ANTIDIABETIC PROPERTIES OF AGERATUM CONYZOIDES LEAVES IN INTRODUCTION : Ageratum conyzoides is an erect herbaceous annual plant . It was originally the treatment of v. 6(May). https://doi.org/10.13040/IJPSR.0975-8232.6(4).1378-87
Ojewale, A., Mada, S., Oyebadejo, S., Afodun, A., Aladeyelu, O., & Kolawole, B. (2020). Cardioprotective Activities of Ethanolic Extract Root of Ageratum conyzoides on Alloxan-Induced Cardiotoxicity in Diabetic Rats. BioMed Research International, 2020. https://doi.org/10.1155/2020/3189672
Olubomehin, O. O., Adeyemi, O. O., & Awokoya, K. N. (2016). Preliminary investigation into the alpha-amylase inhibitory activities of Ageratum conyzoides (Linn.) leaf extracts. Journal of Chemical Society of Nigeria, 41(2), 73–76.
Onsiyor, E. J.-B., Akaffou, N. A., Zahoui, O. S., & Traore, F. (2019). Effets antidiabétiques de l’extrait aqueux de Ageratum conyzoïdes (Astéraceae) chez les rats rendus diabétiques par pancréatectomie partielle et évaluation de leurs paramètres hématologiques. International Journal of Biological and Chemical Sciences, 13(3), 1621. https://doi.org/10.4314/ijbcs.v13i3.33
Oso, B. J., & Olaoye, I. F. (2020). Comparative in vitro studies of antiglycemic potentials and molecular docking of Ageratum conyzoides L. and Phyllanthus amarus L. methanolic extracts. SN Applied Sciences, 2(4), 1–13. https://doi.org/10.1007/s42452-020-2275-5
Parmar, K., Aggarwal, G., & Sharma, U. (2024). α-Glucosidase Inhibiting Chromene Derivatives from Ageratum conyzoides L. Essential Oil Extracted via NADES-Assisted Hydrodistillation. Chemistry and Biodiversity, 202401324. https://doi.org/10.1002/cbdv.202401324
Pay, C., Watuguly, T., & Wael, S. (2022). Potensi Ekstrak Daun Bandotan (Ageratum conyzoides L) Sebagai Obat Diabetes Melitus. Jurnal Biologi Pendidikan Dan Terapan, 9(1), 89–99.
PERKENI. (2021). Pedoman Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 Dewasa di Indonesia 2021. Global Initiative for Asthma, 46. www.ginasthma.org.
Petersmann, A., Nauck, M., Müller-Wieland, D., Kerner, W., Müller, U. A., Landgraf, R., Freckmann, G., & Heinemann, L. (2018). Definition, classification and diagnostics of diabetes mellitus. Journal of Laboratory Medicine, 42(3), 73–79. https://doi.org/10.1515/labmed-2018-0016
Rafe, M. R. (2017). A review of five traditionally used anti-diabetic plants of Bangladesh and their pharmacological activities. Asian Pacific Journal of Tropical Medicine, 10(10), 933–939. https://doi.org/10.1016/j.apjtm.2017.09.002
Sida, A., Kasmawati, H., Idrus, L., & Ruslin. (2023). Lansau : Jurnal Ilmu Kefarmasian ( LJIK ) Potensi Bandotan (Ageratum conyzoides Linn.) sebagai Pencegah. 1(2), 89–100. https://doi.org/10.33772/lansau.v1i2.12
World Health Organization. (n.d.). Diabetes. Retrieved November 15, 2023, from https://www.who.int/health-topics/diabetes#tab=tab_1
Published
2025-01-31
Section
Articles
