Formulasi Nanogel Kurkumin Berbasis Alginat Dialdehid
Abstract
Abstract. Breast cancer is one of the leading causes of death among women in Indonesia. Current chemotherapy treatments often cause toxicity and have low drug bioavailability. This study aims to develop a curcumin nanogel formulation based on dialdehyde alginate as an alternative therapy for breast cancer. Curcumin, which possesses antioxidant and anticancer activities, was formulated using a nanoemulsion encapsulation technique. Dialdehyde alginate obtained through an oxidation process was used to enhance gel stability. The nanogel was evaluated based on particle size, polydispersity index (PDI), and zeta potential. The results showed that the best formula produced particle sizes below 1000 nm (polymeric nanoparticles), PDI values < 0.5, and a zeta potential approaching ±30 mV. The drug release system was controlled, potentially improving the effectiveness of cancer therapy. This nanogel formulation offers an innovative natural-based approach utilizing nanotechnology to overcome the limitations of chemotherapy. Furthermore, this formulation provides advantages such as high penetration, biocompatibility, and biodegradability, making it safe for topical applications. With promising evaluation results, this study makes a significant contribution to the development of nanotechnology-based pharmaceutical preparations, offering a more effective and safer alternative therapy for cancer in the future.
Abstrak. Kanker payudara merupakan salah satu penyebab utama kematian pada wanita di Indonesia. Pengobatan kemoterapi yang tersedia saat ini sering menimbulkan toksisitas dan memiliki bioavailabilitas obat yang rendah. Penelitian ini bertujuan untuk mengembangkan formulasi nanogel kurkumin berbasis alginat dialdehid sebagai alternatif terapi kanker payudara. Kurkumin, yang memiliki aktivitas antioksidan dan antikanker, diformulasikan menggunakan teknik enkapsulasi nanoemulsi. Alginat dialdehid yang diperoleh melalui proses oksidasi digunakan untuk meningkatkan stabilitas gel. Evaluasi nanogel meliputi analisis ukuran partikel, indeks polidispersitas (PDI), dan zeta potensial. Hasil penelitian menunjukkan bahwa formula terbaik menghasilkan ukuran partikel di bawah 1000 nm (nanopartikel polimerik), nilai PDI < 0,5, dan zeta potensial mendekati ±30 mV. Sistem pelepasan obat berlangsung secara terkendali, yang diharapkan mampu meningkatkan efektivitas terapi kanker. Formulasi nanogel ini menawarkan pendekatan inovatif berbasis bahan alam dengan memanfaatkan teknologi nanoteknologi untuk mengatasi keterbatasan pengobatan kemoterapi. Selain itu, formulasi ini memiliki keunggulan berupa penetrasi tinggi, biokompatibilitas, dan biodegradabilitas yang membuatnya aman untuk aplikasi topikal. Dengan hasil evaluasi yang menjanjikan, penelitian ini memberikan kontribusi penting dalam pengembangan sediaan farmasi berbasis nanoteknologi, sehingga diharapkan dapat menjadi alternatif terapi kanker yang lebih efektif dan aman di masa mendatang.
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