Optimasi Formula SNEDDS (Self Nanoemulsifying Drug Delivery System) Minyak Atsiri Bawang Putih
DOI:
https://doi.org/10.29313/bcsp.v4i2.15013Keywords:
SNEDDS, nanoemulsi, minyak atsiri bawang putihAbstract
Abstract. Garlic essential oil is known to contain compounds that can play a role in reducing cholesterol in the body. SNEDDS (Self Nanoemulsifying Drug Delivery System) is a delivery system development for drugs with poor solubility. The SNEDDS component consists of a mixture of oil, surfactant and co-surfactant which will form an O/W nanoemulsion (oil in water) spontaneously when mixed with water accompanied by light stirring. The aim of this research is to obtain a formulation for SNEDDS for garlic essential oil. SNEDDS is formulated using garlic essential oil as the oil phase, tween 20 as the surfactant, and propylene glycol as the co-surfactant.
Abstrak. Minyak atsiri bawang putih diketahui mengandung senyawa yang dapat berperan dalam penurunan kolesterol pada tubuh. SNEDDS (Self Nanoemulsifying Drug Delivery System) adalah salah satu pengembangan sistem penghantaran untuk obat dengan kelarutan yang kurang baik. Komponen SNEDDS terdiri dari campuran minyak, surfaktan, dan ko-surfaktan yang akan membentuk nanoemulsi M/A (minyak dalam air) secara spontan ketika bercampur dengan air disertai dengan pengadukan yang ringan. Tujuan dari penelitian ini yaitu untuk untuk memperoleh formulasi SNEDDS minyak atsiri bawang putih. SNEDDS diformulasikan menggunakan minyak atsiri bawang putih sebagai fase minyak, tween 20 sebagai surfaktan, dan propilenglikol sebagai ko-surfaktan.
References
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[2] Borhade, V., Pathak, S., Sharma., S., Patravale, V. (2012). ‘Clotrimazole Nanoemulasion for Malaria Chemotherapy. Part I: Preformulation Studies, Formulation Design, and Physicochemical Evaluation’, Internasional Journal of Pharmaceutics.
[3] Chintalapudi, R., Murthy, T. E. G., Lakshmi, R. K & Manohar, G. G. (2015). Formulation, Optimization, and Evaluation of Self-Emulsifying Drug Delivery System of Nevirapine. International Journal of Pharmaceutical Investigation, 5(4): 205-213.
[4] Chabib, L., Dimas, A, P., Jamalullail., Nadya, A, H., (2017). Karakterisasi Formulasi SNEDDS Nano Kurkumin Sebagai Anti Artritis Rematoid, Prosiding Seminar Nasional seri 7, Menuju Masyarakat Madani dan Lestari.
[5] Czajkowska-Kosnik, A., Szekalska, M., Amelia, A., Szymanska, E., Winnicka, K. (2015). ‘Development and Evaluation of Liquid and Solid Self-Emulsifying Drug Delivery System for Atorvastatin’. Molecules, Vol. 15. No. 20.
[6] Depkes RI. (2014). Farmakope Indonesia, Edisi V. Jakarta: Departemen Kesehatan Republik Indonesia.
[7] Dyah Ayu Nurismawati, & Sani Ega Priani. (2021). Kajian Formulasi dan Karakterisasi Self-nanoemulsifying Drug Delivery System (SNEDDS) sebagai Penghantar Agen Antihiperlipidemia Oral. Jurnal Riset Farmasi, 1(2), 114–123.
[8] Ernawati, Eli. (2022). Pengaruh Terapi Komplementer Kapsul Minyak Bawang Putih (Allium Sativum) Terhadap Kadar Kolesterol Total Pada Pasien Dislipidemia Di Klinik Desa Sodo Kabupaten Tulungagung. Skripsi. Stikes Karya Putra Bangsa Tulungagung.
[9] Gusnadi, Dedi, O., Taufiq, R., & Baharta, E. (2021). Uji Oranoleptik dan Daya Terima Pada Produk Mousse Berbasis Tapai Singkong Sebegai Komoditi UMKM di Kabupaten Bandung. Jurnal Inovasi Penlitian. Vol 1(12), 2883
[10] Huda, N., & Wahyuningsih, I. (2016). Karakterisasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Minyak Buah Merah (Pandanus conoideus Lam.). Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia, 3(2), 49.
[11] Kumar, M., Bishnoi, R. S., Shukla, A. K., & Jain, C. P. (2019). Techniques For Formulation of Nanoemulsion Drug Delivery System: A review. In Preventive Nutrition and Food Science (Vol. 24, Issue 3). https://doi.org/10.3746/pnf. 2019.24.3.225
[12] Kumar, R. & Soni, G. C. (2017). Formulation development and evaluation of Telmisartan Nanoemulsion. Prajapati International Journal of Research and Development in Pharmacy & Life Science. 4(6). pp. 2711-2719.
[13] Lisiswanti, R., Haryanto, P, F. (2017). Allicin pada Bawang Putih (Allium sativum) sebagai Terapi Alternatif Diabetes Melitus Tipe 2. Majority., Volume 6(2).
[14] Makadia, H. A., Bhatt, A. Y., Parmar, R. B., Paun, J. S., and Tank, H. M. (2013). SelfNano Emulsifying Drug Delivery System (SNEDDS): Future Aspect, Asian Journal of Pharmaceutical Research, Vol. 3, No. 1: 21-27.
[15] Martien, R. et al. (2012) ‘Perkembangan teknologi nanopartikel sebagai sistem penghantaran obat’, Majalah Farmaseutik, 8(1), pp. 133–144.
[16] Nasr, A., Gardouh, A., Ghorab, M. (2016). Effect of Oils, Surfactants and Cosurfactants on Phase Behavior and Physicochemical Properties of Self Nanoemulsifying Drug Delivery System (SNEDDS) for Irbesartan and Olmesartan, International Journal of Applied Pharmaceutics, Vol. 8(1).
[17] Nazari-vanani R, Sattarahmady N, Azarpira N, dan Heli H. (2018). Introducing Self-Nanoemulsifying Drug Delivery System to Increase the Bioavailability of Oral Medications. Jorjani Biomedicine Journal, 6(3), 1–13.
[18] Priani, S. E., Nurrayan, Darusman, F. (2017). ‘Formulation Delf Nano Emulsifying Drug Delivery System Glipepiride Using Oleic Acid as Oil Phase’, Pahrmaciana, Vol.7. No.2
[19] Rahmawati, R. (2012). Keampuhan Bawang Putih Tunggal (Bawang Lanang). Yogyakarta: Pustaka Baru Press.
[20] Riafiana, Fadillah. (2017). Efek Ekstrak Bawang Putih (Allium sativum L) Terhadap Kadar LDL dan HDL Hepar Tikus. Skripsi. Jakarta: Universitas Islam Negeri Syarif Hidayatullah.
[21] Rudiartha, I. L. M., & Setiawan, P. Y. B. (2023). Perbaikan Profil Lipid pada Masyarakat Muslim Hiperlipidemia dengan Puasa Ramadhan di Denpasar Selatan. Indonesian Journal of Pharmaceutical Education (e-Journal), 3(3), 2775–3670.
[22] Satyal, P., Craft, J. D., Dosoky, N. S., & Setzer, W. N. (2017). The Chemical Compositions of The Volatile Oils of Garlic (Allium Sativum) and Wild Garlic (Allium vineale). Foods, 6(8), 1-10.
[23] Sahumena, M. H., Suryani., Rahmadani, N. (2019). ‘Formulasi Self-Nanoemulsifying Drug Delivery System (SNEDDS) Asam Mefenamat menggunakan VCO dengan Kombinasi Surfaktan Tween dan Span’, Journal Syifa Sciences and Clinical Research, Vol. 1, NO. 2
[24] Seema, G. dan Kuma, S.A. (2014). Self-Nanoemulsifying Drug Delivery System an Noval Approach For Improving Bioavailability, Journal of Drug Delivery & Therapeutics, Vol. 4(6).
[25] Sarwindah, D. (2020). Potensi Seledri Sebagai Anti Kolesterol. Jurnal Penelitian Perawat Profesional, 2(4), Hal 571 – 578 Global Health Science Group. https://jurnal.globalhealthsciencegroup.com/index.php/JPPP/article/download/217/159/
[26] Singh, R., Liliard, J. (2009). Nanoparticle-based targeted drug delivery. Exp Mol Pathol, 215-223.
[27] WHO. (2019). Cardiovascular Diseases. World Health Organization the Global Healt
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2024-08-15
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