Modifikasi Natrium Alginat dengan Metode Oksidasi Periodat
DOI:
https://doi.org/10.29313/bcsp.v4i2.14241Keywords:
Natrium Alginat, Alginat Dialdehida, Natrium MetaperiodatAbstract
Abstract. This research aims to modify sodium alginate using the periodate oxidation method. The alginate used is not easily biodegradable, so oxidation is carried out with sodium metaperiodate to facilitate biodegradation and produce new functional groups. With the presence of new functional groups in alginate, hydrogels can be formed using type B gelatin and BaCl2. Alginate was successfully synthesized because an oxidation degree of 3% was obtained and the Fourier Transform Infra Red Attenuated Total Reflectance (FTIR-ATR) results showed a band of 1720 cm-1 which indicated a change in alginate to Alginate Dialdehyde (ADA).
Abstrak. Penelitian ini bertujuan untuk modifikasi natrium alginat dengan metode oksidasi periodat. Alginat yang digunakan tidak mudah terbiodegradasi, sehingga dilakukan oksidasi dengan natrium metaperiodat untuk mempermudah biodegradasi dan menghasilkan gugus fungsi baru. Dengan adanya gugus fungsi baru pada alginat maka hidrogel dapat dibentuk dengan menggunakan gelatin tipe B dan BaCl2. Alginat berhasil disintesis karena diperoleh derajat oksidasi 3% dan hasil Fourier Transform Infra Red Attenuated Total Reflectance (FTIR-ATR) menunjukkan pita 1720 cm-1 yang menunjukkan adanya perubahan alginat menjadi Alginat Dialdehida (ADA).
References
[2] Balakrishnan, B., Lesieur, S., Labarre, D., & Jayakrishnan, A. (2005). Periodate Oxidation of Sodium Alginate in Water and in Ethanol-Water Mixture: A Comparative Study. Carbohydrate Research, 340(7), 1425–1429. https://doi.org/10.1016/j.carres.2005.02.028
[3] Ding, W., Zhou, J., Zeng, Y., Wang, Y. nan, & Shi, B. (2017). Preparation of oxidized sodium alginate with different molecular weights and its application for crosslinking collagen fiber. Carbohydrate Polymers, 157, 1650–1656. https://doi.org/10.1016/j.carbpol.2016.11.045
[4] Emami, Z., Ehsani, M., Zandi, M., & Foudazi, R. (2018). Controlling Alginate Oxidation Conditions for Making Alginate-Gelatin Hydrogels. Carbohydrate Polymers, 198, 509–517. https://doi.org/10.1016/j.carbpol.2018.06.080
[5] Kara Ozenler, A., Distler, T., Tihminlioglu, F., & Boccaccini, A. R. (2023). Fish Scale Containing Alginate Dialdehyde-Gelatin Bioink for Bone Tissue Engineering. Biofabrication, 15(2). https://doi.org/10.1088/1758-5090/acb6b7
[6] Kolo, S. M. D., Obenu, N. M., & Rohy, N. T. (2022). Pengaruh Perlakuan Awal Ampas Biji Jewawut (Setaria italica L.) dengan Microwave Irradiation Untuk Produksi Bioetanol. ALCHEMY Jurnal Penelitian Kimia, 18(2), 183. https://doi.org/10.20961/alchemy.18.2.59819.183-192
[7] Labowska, M. B., Cierluk, K., Jankowska, A. M., Kulbacka, J., Detyna, J., & Michalak, I. (2021). A Review on the Adaption of Alginate-Gelatin Hydrogels for 3D Cultures and Bioprinting. Materials, 14(4), 1–28. https://doi.org/10.3390/ma14040858
[8] Mehedi Hasan, M., Nuruzzaman Khan, M., Haque, P., & Rahman, M. M. (2018). Novel Alginate-Di-Aldehyde Cross-Linked Gelatin/Nano-Hydroxyapatite Bioscaffolds for Soft Tissue Regeneration. International Journal of Biological Macromolecules, 117, 1110–1117. https://doi.org/10.1016/j.ijbiomac.2018.06.020
[9] Mohamed, M. A., Jaafar, J., Ismail, A. F., Othman, M. H. D., & Rahman, M. A. (2017). Fourier Transform Infrared (FTIR) Spectroscopy. In Membrane Characterization. Elsevier B.V. https://doi.org/10.1016/B978-0-444-63776-5.00001-2
[10] Pasaribu, S. P., Dialdehid, S., Fmipa Unmul, K., Kaban, J., Ginting, M., & Sinaga, K. R. (2017). Sintesis Dialdehid Alginat Melalui Reaksi Oksidasi Natrium Alginat dengan Natrium Metaperiodat. Jurnal Kimia Mulawarman, 14 (2).
[11] Permanadewi, I., Kumoro, A. C., Wardhani, D. H., & Aryanti, N. (2021). Analysis of Temperature Regulation, Concentration, and Stirring Time at Atmospheric Pressure to Increase Density Precision of Alginate Solution. Teknik, 42(1), 29–34. https://doi.org/10.14710/teknik.v42i1.35994
[12] Prastyo, P., & Sri Rahayoe, A. (2018). Penyaringan Metode Buchner Sebagai Alternatif Pengganti Penyaringan Sederhana Pada Percobaan Adsorpsi Dalam Pratikum Kimia Fisika. Indonesian Journal of Laboratory, 1(1), 24. https://doi.org/10.22146/ijl.v1i1.40966
[13] Putri, A. P., Bose, R. K., Chalid, M., & Picchioni, F. (2023). Rheological and Self-Healing Behavior of Hydrogels Synthesized from l-Lysine-Functionalized Alginate Dialdehyde. Polymers, 15(4), 1–15. https://doi.org/10.3390/polym15041010
[14] Rajalekshmi, R., Kaladevi Shaji, A., Joseph, R., & Bhatt, A. (2021). Scaffold for Liver Tissue Engineering: Exploring the Potential of Fibrin Incorporated Alginate Dialdehyde–Gelatin Hydrogel. International Journal of Biological Macromolecules, 166, 999–1008. https://doi.org/10.1016/j.ijbiomac.2020.10.256
[15] Subaryono. (2010). Modifikasi Alginat dan Pemanfaatan Produknya. Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology, 5(1), 1–7.
[16] Sulistyani, M., & Huda, N. (2018). Perbandingan Metode Transmisi dan Reflektansi Pada Pengukuran Polistirena Menggunakan Instrumentasi Spektroskopi Fourier Transform Infra Red. Indonesian Journal of Chemical Science, 7(2), 195–198.
[17] Wahyuningsih, E., & Dessidianti, R. (2022). Aplikasi FT-IR ATR Spektroskopi untuk Identifikasi Parasetamol pada Jamu Sediaan Serbuk Application of FT-IR ATR Spectroscopy to Identificate Paracetamol in Herbal Powder Preparations. Camellia, 1(2), 56–60.
[18] Wilkerson, M. Y. (2022). Properties and Applications of Alginate. Properties and Applications of Alginate, 1–181. https://doi.org/10.5772/intechopen.94635
[19] Winangsih, Prihastanti, E., & Parman, S. (2013). Pengaruh Metode Pengeringan Terhadap Kualitas Simplisia. Buletin Anatomi Dan Fisiologi, 21(1), 19–25.
[20] Zhaafirah, H., Fitriyano, G., & Hasyim, U. H. (2017). Pengaruh Kecepatan Pengadukan terhadap Rendemen dan Identifikasi Selulosa Asetat Hasil Asetilasi dari Limbah Kulit Pisang Kepok. Jurnal UMJ, November, 1–8. https://jurnal.umj.ac.id/index.php/semnastek/article/view/2041
