Aktivitas Antidiabetes Tanaman Rosemary (Rosmarinus officinalis L.)
DOI:
https://doi.org/10.29313/bcsp.v4i2.13616Keywords:
Rosmarinus officinalis, Antidiabetes, In VivoAbstract
Abstract. Diabetes is a chronic disease characterized by increased blood glucose levels in the body because the pancreas is unable to produce insulin or the body is unable to use insulin optimally. Plants that have antidiabetic activity are rosemary plants (Rosmarinus officinalis L.) which come from the Lamiaceae tribe and the Rosmarinus clan. The purpose of this literature search is to identify how the potential of rosemary plants (Rosmarinus officinalis L.) in overcoming diabetes mellitus. The method used is a literature search by searching for articles that have been published in national and international journals through electronic data such as Google Scholar, PubMed, Science Direct, Springer, and Scopus. The results of the literature search showed that leaf extracts and herb extracts of rosemary plants have antidiabetic activity by reducing blood glucose levels and increasing insulin levels. Then, the active compound in rosemary that has potential as an antidiabetic is rosmarinic acid.
Abstrak. Diabetes merupakan penyakit kronis yang ditandai dengan peningkatan kadar glukosa darah dalam tubuh karena pankreas tidak mampu menghasilkan insulin atau tubuh tidak mampu menggunakan insulin secara optimal. Tanaman yang memiliki aktivitas antidiabetes yaitu tanaman rosemary (Rosmarinus officinalis L.) yang berasal dari suku Lamiaceae dan marga Rosmarinus. Tujuan dari penelusuran pustaka ini adalah untuk mengidentifikasi bagaimana potensi tanaman rosemary (Rosmarinus officinalis L.) dalam mengatasi penyakit diabetes melitus. Metode yang digunakan adalah penelusuran pustaka dengan mencari artikel yang telah diterbitkan dalam jurnal nasional maupun internasional melalui data elektronik seperti Google Scholar, PubMed, Science Direct, Springer, dan Scopus. Hasil dari penelusuran pustaka menunjukkan bahwa ekstrak daun dan ekstrak herba tanaman rosemary memiliki aktivitas antidiabetes dengan cara menurunkan kadar glukosa darah dan meningkatkan kadar insulin. Kemudian, senyawa aktif dalam rosemary yang berpotensi sebagai antidiabetes adalah asam rosmarinat.
References
[2] American Diabetes Association. (2020). Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2020. Diabetes Care, 43(January), 14–S31. https://doi.org/10.2337/dc20-S002
[3] Wijayanti S. P. M., Nurbaiti, T. T., & Maqfiroch, A. F. A. (2020). Analisis Faktor Risiko Kejadian Diabetes Mellitus Tipe II di Wilayah Pedesaan. Jurnal Promosi Kesehatan Indonesia, 15(1), 16. https://doi.org/10.14710/jpki.15.1.16-21
[4] Kemenkes RI. (2020). Infodatin 2020 Diabetes Melitus Pusat Data dan Informasi Kementerian Kesehatan RI. Kementrian Kesehatan Republik Indonesia.
[5] Naimi, M., Vlavcheski, F., Shamshoum, H., & Tsiani, E. (2017). Rosemary Extract As a Potential Anti-hyperglycemic Agent: Current Evidence and Future Perspectives. Nutrients, 9(9), 1–19. https://doi.org/10.3390/nu9090968
[6] Nazem F., Farhangi, N., & Gharameleki, M. N. (2015). Beneficial effects of endurance exercise with Rosmarinus officinalis Labiatae leaves extract on blood antioxidant enzyme activities and lipid peroxidation in streptozotocin-induced diabetic rats. Can J Diabetes, 1-6. http://dx.doi.org/10.1016/j.jcjd.2014.11.003
[7] Ramadan, K. S., Khalil, O. A., Danial, E. N., Alnahdi, H. S., & Ayaz, N. O. (2013). Hypoglycemic and hepatoprotective activity of Rosmarinus officinalis extract in diabetic rats. Journal of physiology and biochemistry, 69, 779-783.
[8] Khalil O. A., Ramadan, K. S., Danial, E. N., Alnahdi, H. S., & Ayaz, N. O. (2013). Antidiabetic activity of Rosmarinus officinalis and its relationship with the antioxidant property. African Journal of Pharmacy and Pharmacology, 6(14), 1031-1036.
[9] Rasoulian B., Hajializadeh, Z., Esmaeili-Mahani, S., Rashidipour, M., Fatemi, I., & Kaeidi, A. (2019). Neuroprotective and antinociceptive effects of rosemary (Rosmarinus officinalis L.) extract in rats with painful diabetic neuropathy. The journal of physiological sciences, 69, 57-64. https://doi.org/10.1007/s12576-018-0620-x
[10] ElBoshy, M. S., Header, E. A., ElSawy, N. A., Basalamah, M. B., Mubarak, M. S., & Hadda, T. (2015). Studies on the constituents of Rosmarinus officinalis and their synergistic effect in experimental diabetic rats. J Invest Biochem, 4(1), 36-43.
[11] Shen, Y., Han, J., Zheng, X., Ai, B., Yang, Y., Xiao, D., ... & Sheng, Z. (2020). Rosemary leaf extract inhibits glycation, breast cancer proliferation, and diabetes risks. Applied Sciences, 10(7), 2249.
[12] Ginting, A. F., Suryanto, E., & Momuat, L. I. (2015). Aktivitas antioksidan ekstrak air dan etanol dari empelur batang Sagu Baruk (Arenga microcarpha). Chemistry Progress, 8(2), 48-54 https://doi.org/10.35799/cp.8.2.2015.13265
[13] Rafsanjani, M. K., & Putri, W. D. R. (2015). Karakterisasi ekstrak kulit jeruk bali menggunakan metode ultrasonic bath (kajian perbedaan pelarut dan lama ekstraksi). Jurnal Pangan dan Agroindustri, 3(4), 1473-1480
[14] Tapalina, N., Tutik, T., & Saputri, G. A. R. (2022). Pengaruh Metode Ekstraksi Panas Terhadap Aktivitas Antioksidan Ekstrak Kulit Bawang Merah (Allium Cepa L.). Jurnal Ilmu Kedokteran Dan Kesehatan, 9(1)
[15] Susanti, N. M. P., Budiman, I. N. A., & Warditiani, N. K. (2014). Skrining fitokimia ekstrak etanol 90% daun katuk (Sauropus androgynus (L.) Merr.). Jurnal Farmasi Udayana, 3(1), 279778.
[16] Novita, R., Kasim, A., Anggraini, T., & Putra, D. P. (2018). Survei proses pembuatan minuman kahwa daun di Propinsi Sumatera Barat, Indonesia. Jurnal teknologi pertanian andalas, 22(1), 32-36.
[17] Lestari, E. D., Tivani, I., & Susiyarti, S. (2021). Perbandingan Efektivitas Antibakteri Ekstrak Maserasi Dan Refluks Daun Pepaya (Carica papaya L.) Terhadap Bakteri Staphylococcus aureus (Doctoral dissertation, DIII Farmasi Politeknik Harapan Bersama).
[18] Pargiyanti, P. (2019). Optimasi waktu ekstraksi lemak dengan metode soxhlet menggunakan perangkat alat mikro soxhlet. Indonesian Journal of Laboratory, 1(2), 29-35.
[19] Marliza, H., Sammulia, S. F., & Mayefis, D. (2023). Analisis Proksimat Dan Skrining Fitokimia Tumbuhan Di Perairan Pantai Sekilak Kota Batam. The Journal General Health and Pharmaceutical Sciences Research, 1(2), 41- 54. https://doi.org/10.57213/tjghpsr.v1i2.225
[20] Malek, A., M Sadaka, M. W., Hamo, S., & Al-Mahbashi, H. M. (2021). Evaluation of Antidiabetic Activity of Rosmarinus officinalis var. prostratus Growing in Syria in Alloxan Diabetic Rats. Current Bioactive Compounds, 17(2), 187-193.
[21] Shufyani, F., Wahyuni, F. S., & Armal, K. (2017). Evaluasi faktor-faktor yang mempengaruhi kejadian hipoglikemia pada pasien diabetes mellitus tipe 2 yang menggunakan insulin. SCIENTIA: Jurnal farmasi dan kesehatan, 7(1).
[22] Sukarno, D. A. (2021). Pengaruh Latihan Fisik terhadap Perbaikan Resistensi Insulin. Keluwih: Jurnal Kesehatan dan Kedokteran, 2(2), 108-112.
[23] Klip, A., McGraw, T. E., & James, D. E. (2019). Thirty sweet years of GLUT4. Journal of Biological Chemistry, 294(30), 11369-11381.
[24] Munaeni, W., Mainassy, M. C., Puspitasari, D., Susanti, L., Endriyatno, N. C., Yuniastuti, A., & Hendra, G. A. (2022). Perkembangan Dan Manfaat Obat Herbal Sebagai Fitoterapi. Tohar Media.
[25] Belmouhoub, M., Bribi, N., & Iguer-ouada, M. (2017). Alpha-glucosidase inhibition and antihyperglycemic activity of flavonoids rich fractions of Rosmarinus officinalis in normal and streptozotocin diabetic mice. Oriental Pharmacy and Experimental Medicine, 17, 29-39. http://dx.doi.org/10.1007/s13596-016-0252-8
[26] Belmouhoub M., Chebout, I., & Iguer-Ouada, M. (2018). Antidiabetic and anti-hypercholesterolemic effects of flavonoid-rich fractions of Rosmarinus officinalis in streptozotocin-induced diabetes in mice. Phytotherapie, 16(4), 204.
[27] Azhar, M. K., Anwar, S., Hasan, G. M., Shamsi, A., Islam, A., Parvez, S., & Hassan, M. I. (2023). Comprehensive insights into biological roles of rosmarinic acid: implications in diabetes, cancer and neurodegenerative diseases. Nutrients, 15(19), 4297