Kajian Formulasi Sediaan Gel Mata In Situ Termosensitif untuk Pengobatan Glaukoma
DOI:
https://doi.org/10.29313/bcsp.v4i2.13470Keywords:
Gel in situ termosensitif, Glaukoma, Tekanan IntraokularAbstract
Abstract. The main treatment for glaucoma is conventional eye drops. However, these drops have limitations such as short contact time, which can result in uncontrolled intraocular pressure. To improve the effectiveness of treatment, preparations that increase contact time are needed. One preparation that can be used to overcome the weaknesses of eye drop preparations is in situ thermosensitive eye gel. The research method used to assess this is a systematic literature review of leading national and international journals from various databases. The study literature results showed that a combination polymer poloxamer 407 (15,5-24,25%)-poloxamer 188 (1,5-5%) and poloxamer 407 (16-20%)-HPMC (0,15-1%) is an optimum polymer used for in situ thermosensitive eye gel preparations.
Abstrak. Sediaan tetes mata konvensional merupakan pilihan pengobatan utama untuk glaukoma. Namun, tetes mata memiliki kelemahan seperti waktu kontak yang singkat, sehingga dapat mengakibatkan tekanan intraokular tidak terkendali secara signifikan. Oleh karena itu, diperlukan sediaan yang dapat meningkatkan waktu kontak sehingga efek terapi dapat tercapai. Salah satu sediaan yang dapat digunakan untuk mengatasi kelemahan sediaan obat tetes mata adalah gel mata in situ termosensitif. Metode penelitian yang digunakan yaitu systematic literature review berdasarkan jurnal nasional dan internasional yang berasal dari data base bereputasi. Hasil kajian menunjukkan bahwa kombinasi poloxamer 407 (15,5-24,25%)-poloxamer 188 (1,5-5%) serta poloxamer 407 (16-20%)-HPMC (0,15-1%) merupakan kombinasi polimer yang optimum untuk sediaan gel mata in situ termosensitif. Berdasarkan hasil ini, sediaan gel mata termosensitif in situ dapat menjadi pilihan yang layak untuk pengobatan glaukoma.
References
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[12] Shubhra, Q. T. H., Tóth, J., Gyenis, J., & Feczkó, T. (2014). Poloxamers for Surface Modification of Hydrophobic Drug Carriers and Their Effects on Drug Delivery. Polymer Reviews, 54(1), 112–138. https://doi.org/10.1080/15583724.2013.862544.
[13] Huang, W., Zhang, N., Hua, H., Liu, T., Tang, Y., Fu, L., Yang, Y., Ma, X., & Zhao, Y. (2016). Preparation, Pharmacokinetics and Pharmacodynamics of Ophthalmic Thermosensitive In Situ hydrogel of Betaxolol Hydrochloride. Biomedicine and Pharmacotherapy, 83, 107–113. https://doi.org/10.1016/j.biopha.2016.06.024.
[14] Zeng, Y., Chen, J., Li, Y., Huang, J., Huang, Z., Huang, Y., Pan, X., & Wu, C. (2018). Thermo-sensitive Gel In Glaucoma Therapy for Enhanced Bioavailability: In vitro Characterization, In Vivo Pharmacokinetics and Pharmacodynamics Study. Life Sciences, 212, 80–86. https://doi.org/10.1016/j.lfs.2018.09.050.
[15] Abdeltawab, H., Svirskis, D., Hill, A. G., & Sharma, M. (2022). Increasing the Hydrophobic Component of Poloxamers and the Inclusion of Salt Extend the Release of Bupivacaine from Injectable In Situ Gels, While Common Polymer Additives Have Little Effect. Gels, 8(8). https://doi.org/10.3390/gels8080484.
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[17] Sathyanarayana, S. D., Rompicherla, N. C., Vadakkepushpakath, A. N., & Nayak, P. (2020). Development of Thermosensitive Ophthalmic in Situ Gels of Bimatoprost for Glaucoma Therapy. Indian Journal of Pharmaceutical Education and Research, 54(2), S154–S162. https://doi.org/10.5530/ijper.54.2s.71.
[18] Khallaf, A. M., El-Moslemany, R. M., Ahmed, M. F., Morsi, M. H., & Khalafallah, N. M. (2022). Exploring a Novel Fasudil-Phospholipid Complex Formulated as Liposomal Thermosensitive in situ Gel for Glaucoma. International Journal of Nanomedicine, 17, 163–181. https://doi.org/10.2147/IJN.S342975.
[19] Khattab, A., Marzok, S., & Ibrahim, M. (2019). Development of Optimized Mucoadhesive Thermosensitive Pluronic Based In Situ Gel for Controlled Delivery of Latanoprost: Antiglaucoma efficacy and stability approaches. Journal of Drug Delivery Science and Technology, 53. https://doi.org/10.1016/j.jddst.2019.101134.
[20] Bruschi, M. L., Borghi-Pangoni, F. B., Junqueira, M. V, De, S. B., & Ferreira, S. (2017). Chapter 12 - Nanostructured Therapeutic Systems with Bioadhesive and Thermoresponsive Properties. In Nanostructures for Novel Therapy. https://doi.org/10.1016/B978-0-323-46142-9/00012-8.
[21] Agrawal, M., Saraf, S., Saraf, S., Dubey, S. K., Puri, A., Gupta, U., Kesharwani, P., Ravichandiran, V., Kumar, P., Naidu, V. G. M., Murty, U. S., Ajazuddin, & Alexander, A. (2020). Stimuli Responsive In Situ Gelling System for Nose-to Brain Drug Delivery. In Journal of Controlled Release. 327: 235–265.
[22] Konatham, M., Gorle, M. T., Pathakala, N., Bakshi, V., Mamidisetti, Y. D., Chinthakindi, P., & Jadi, R. K. (2021). In situ gel polymers: A Review. International Journal of Applied Pharmaceutics, 13(1), 86–90. https://doi.org/10.22159/ijap.2021v13i1.39504
[23] Harugade, A., Sherje, A. P., & Pethe, A. (2023). Chitosan: A Review on Properties, Biological Activities and Recent Progress in Biomedical Applications. In Reactive and Functional Polymers, 191.
[24] Cheng, R., Xu, T., Wang, C., & Gan, C. (2021). The Stabilization and Antioxidant Performances of Coenzyme Q10-Loaded Niosomes Coated by PEG and Chitosan. Journal of Molecular Liquids, 325. https://doi.org/10.1016/j.molliq.2020.115194
[25] Chatterjee, S., Hui, P. C. L., & Kan, C. wai. (2018). Thermoresponsive Hydrogels and Their Biomedical Applications: Special Insight Into Their Applications in Textile Based Transdermal Therapy. In Polymers, 10 (5). https://doi.org/10.3390/polym10050480.
[26] Hamzah, A., Sitompul, L. L., Putri, F. N. I., Soeprijanto., Widjaja, A. (2019). Synergistic Effect of Two Type Cellulase Immobilized on Chitosan Microparticle as Biocatalyst for Coconut Husk Hydrolysis. Indones. J. Chem, 19(2), 495-502.
[27] Sharma, P. K., & Chauhan, M. K. (2021). Optimization and Characterization of Brimonidine Tartrate Nanoparticles-loaded In Situ Gel for the Treatment of Glaucoma. Current Eye Research, 46(11), 1703–1716. https://doi.org/10.1080/02713683.2021.1916037.
[28] Cheng, Y. H., Tsai, T. H., Jhan, Y. Y., Chiu, A. W. H., Tsai, K. L., Chien, C. S., Chiou, S. H., & Liu, C. J. L. (2016). Thermosensitive Chitosan-Based Hydrogel as a Topical Ocular Drug Delivery System of Latanoprost for Glaucoma Treatment. Carbohydrate. Polymers, 144, 390–399. https://doi.org/10.1016/j.carbpol.2016.02.080.
[29] Bachhav, H. D. , Savkare, A. , Karmarkar, R. , & Derle, D. (2015). Development of Poloxamer Based Thermosensitive In Situ Ocular Gel of Betaxolol Hydrochloride. International Journal of Pharmacy and Pharmaceutical Sciences, 7(6), 287–291.
[30] El-Feky, Y. A., Fares, A. R., Zayed, G., El-Telbany, R. F. A., Ahmed, K. A., & El-Telbany, D. F. A. (2021). Repurposing of Nifedipine Loaded In Situ Ophthalmic Gel as a Novel Approach for Glaucoma Treatment. Biomedicine and Pharmacotherapy, 142. https://doi.org/10.1016/j.biopha.2021.112008.
[31] Li, J., Liu, H., Liu, l. l., Cai, N. C., Xin, X. H., Liu, W. (2014). Design and Evaluation of a Brinzolamide Drug–Resin in Situ Thermosensitive Gelling System for Sustained Ophthalmic Drug Delivery. Chem. Pharm. Bull, 62(10), 1001-1008.
[32] Talaei, S., Mahboobian, M. M., & Mohammadi, M. (2020). Investigating the Ocular Toxicity Potential and Therapeutic Efficiency of In Situ Gel Nanoemulsion Formulations of Brinzolamide. Toxicology Research, 9(4), 578–587. https://doi.org/10.1093/TOXRES/TFAA066.
[2] Singh, M., Dev, D., & Prasad, D. N. (2021). A Recent Overview: In Situ Gel Smart Carriers for Ocular Drug Delivery. Journal of Drug Delivery and Therapeutics, 11(6-S), 195–205. https://doi.org/10.22270/jddt.v11i6-s.5147.
[3] Arora, K., Singh, L., & Author, C. (2023). Formulation Development And Characterization Of In Situ Gel Containing Bimatoprost For The Treatment Of Glaucoma. Journal of Pharmaceutical Negative Results, 14(02), 1986–2001. https://doi.org/10.47750/pnr.2023.14.02.247.
[4] Insan, S. K., Iyan, S., Wahyu, A. A., Nuraini, H., Fikri, D. A., & Anggun, N. (2018). Preformed Gel vs In Situ Gel: A Review. International Research Journal Of Pharmacy, 9(8), 1–5. https://doi.org/10.7897/2230-8407.098155.
[5] Cassano, R., Di Gioia, M. L., & Trombino, S. (2021). Gel-based Materials for Ophthalmic Drug Delivery. In Gels, 7,(3). https://doi.org/10.3390/gels7030130.
[6] Almutairy, B. K., Khafagy, E. S., & Abu Lila, A. S. (2023). Development of Carvedilol Nanoformulation-Loaded Poloxamer-Based In Situ Gel for the Management of Glaucoma. Gels, 9(12). https://doi.org/10.3390/gels9120952.
[7] Irmia, T., Ghica, V. M., Popa, L., Anuta, V., Arsene, L. A., Pîrvu, D. E. C. (2018). Strategies for Improving Ocular Drug Bioavailability and Corneal Wound Healing with Chitosan-Based Delivery Systems. Polymers, 10, (1221).
[8] Chen, Y., Lee, J. H., Meng, M., Cui, N., Dai, C. Y., Jia, Q., Lee, E. S., & Jiang, H. B. (2021). An Overview On Thermosensitive Oral Gel Based on Poloxamer 407. In Materials. 14(16). https://doi.org/10.3390/ma14164522.
[9] Yadav, M., Guzman-Aranguez, A., Perez de Lara, M. J., Singh, M., Singh, J., & Kaur, I. P. (2019). Bimatoprost Loaded Nanovesicular Long-Acting Sub-Conjunctival In-Situ Gelling Implant: In Vitro and In Vivo Evaluation. Materials Science and Engineering, 103. https://doi.org/10.1016/j.msec.2019.05.015.
[10] Dewan, M., Adhikari, A., Jana, R., & Chattopadhyay, D. (2023). Development, Evaluation and Recent Progress of Ocular In Situ Gelling Drug Delivery Vehicle Based on Poloxamer 407. In Journal of Drug Delivery Science and Technology, 88, https://doi.org/10.1016/j.jddst.2023.104885.
[11] Russo, E., & Villa, C. (2019). Poloxamer hydrogels for biomedical applications. In Pharmaceutics. 11(12). https://doi.org/10.3390/pharmaceutics11120671.
[12] Shubhra, Q. T. H., Tóth, J., Gyenis, J., & Feczkó, T. (2014). Poloxamers for Surface Modification of Hydrophobic Drug Carriers and Their Effects on Drug Delivery. Polymer Reviews, 54(1), 112–138. https://doi.org/10.1080/15583724.2013.862544.
[13] Huang, W., Zhang, N., Hua, H., Liu, T., Tang, Y., Fu, L., Yang, Y., Ma, X., & Zhao, Y. (2016). Preparation, Pharmacokinetics and Pharmacodynamics of Ophthalmic Thermosensitive In Situ hydrogel of Betaxolol Hydrochloride. Biomedicine and Pharmacotherapy, 83, 107–113. https://doi.org/10.1016/j.biopha.2016.06.024.
[14] Zeng, Y., Chen, J., Li, Y., Huang, J., Huang, Z., Huang, Y., Pan, X., & Wu, C. (2018). Thermo-sensitive Gel In Glaucoma Therapy for Enhanced Bioavailability: In vitro Characterization, In Vivo Pharmacokinetics and Pharmacodynamics Study. Life Sciences, 212, 80–86. https://doi.org/10.1016/j.lfs.2018.09.050.
[15] Abdeltawab, H., Svirskis, D., Hill, A. G., & Sharma, M. (2022). Increasing the Hydrophobic Component of Poloxamers and the Inclusion of Salt Extend the Release of Bupivacaine from Injectable In Situ Gels, While Common Polymer Additives Have Little Effect. Gels, 8(8). https://doi.org/10.3390/gels8080484.
[16] Fakhari, A., Corcoran, M., Schwarz, A. (2017). Thermogelling Properties of Purified Poloxamer 407. Heliyon, e00390.
[17] Sathyanarayana, S. D., Rompicherla, N. C., Vadakkepushpakath, A. N., & Nayak, P. (2020). Development of Thermosensitive Ophthalmic in Situ Gels of Bimatoprost for Glaucoma Therapy. Indian Journal of Pharmaceutical Education and Research, 54(2), S154–S162. https://doi.org/10.5530/ijper.54.2s.71.
[18] Khallaf, A. M., El-Moslemany, R. M., Ahmed, M. F., Morsi, M. H., & Khalafallah, N. M. (2022). Exploring a Novel Fasudil-Phospholipid Complex Formulated as Liposomal Thermosensitive in situ Gel for Glaucoma. International Journal of Nanomedicine, 17, 163–181. https://doi.org/10.2147/IJN.S342975.
[19] Khattab, A., Marzok, S., & Ibrahim, M. (2019). Development of Optimized Mucoadhesive Thermosensitive Pluronic Based In Situ Gel for Controlled Delivery of Latanoprost: Antiglaucoma efficacy and stability approaches. Journal of Drug Delivery Science and Technology, 53. https://doi.org/10.1016/j.jddst.2019.101134.
[20] Bruschi, M. L., Borghi-Pangoni, F. B., Junqueira, M. V, De, S. B., & Ferreira, S. (2017). Chapter 12 - Nanostructured Therapeutic Systems with Bioadhesive and Thermoresponsive Properties. In Nanostructures for Novel Therapy. https://doi.org/10.1016/B978-0-323-46142-9/00012-8.
[21] Agrawal, M., Saraf, S., Saraf, S., Dubey, S. K., Puri, A., Gupta, U., Kesharwani, P., Ravichandiran, V., Kumar, P., Naidu, V. G. M., Murty, U. S., Ajazuddin, & Alexander, A. (2020). Stimuli Responsive In Situ Gelling System for Nose-to Brain Drug Delivery. In Journal of Controlled Release. 327: 235–265.
[22] Konatham, M., Gorle, M. T., Pathakala, N., Bakshi, V., Mamidisetti, Y. D., Chinthakindi, P., & Jadi, R. K. (2021). In situ gel polymers: A Review. International Journal of Applied Pharmaceutics, 13(1), 86–90. https://doi.org/10.22159/ijap.2021v13i1.39504
[23] Harugade, A., Sherje, A. P., & Pethe, A. (2023). Chitosan: A Review on Properties, Biological Activities and Recent Progress in Biomedical Applications. In Reactive and Functional Polymers, 191.
[24] Cheng, R., Xu, T., Wang, C., & Gan, C. (2021). The Stabilization and Antioxidant Performances of Coenzyme Q10-Loaded Niosomes Coated by PEG and Chitosan. Journal of Molecular Liquids, 325. https://doi.org/10.1016/j.molliq.2020.115194
[25] Chatterjee, S., Hui, P. C. L., & Kan, C. wai. (2018). Thermoresponsive Hydrogels and Their Biomedical Applications: Special Insight Into Their Applications in Textile Based Transdermal Therapy. In Polymers, 10 (5). https://doi.org/10.3390/polym10050480.
[26] Hamzah, A., Sitompul, L. L., Putri, F. N. I., Soeprijanto., Widjaja, A. (2019). Synergistic Effect of Two Type Cellulase Immobilized on Chitosan Microparticle as Biocatalyst for Coconut Husk Hydrolysis. Indones. J. Chem, 19(2), 495-502.
[27] Sharma, P. K., & Chauhan, M. K. (2021). Optimization and Characterization of Brimonidine Tartrate Nanoparticles-loaded In Situ Gel for the Treatment of Glaucoma. Current Eye Research, 46(11), 1703–1716. https://doi.org/10.1080/02713683.2021.1916037.
[28] Cheng, Y. H., Tsai, T. H., Jhan, Y. Y., Chiu, A. W. H., Tsai, K. L., Chien, C. S., Chiou, S. H., & Liu, C. J. L. (2016). Thermosensitive Chitosan-Based Hydrogel as a Topical Ocular Drug Delivery System of Latanoprost for Glaucoma Treatment. Carbohydrate. Polymers, 144, 390–399. https://doi.org/10.1016/j.carbpol.2016.02.080.
[29] Bachhav, H. D. , Savkare, A. , Karmarkar, R. , & Derle, D. (2015). Development of Poloxamer Based Thermosensitive In Situ Ocular Gel of Betaxolol Hydrochloride. International Journal of Pharmacy and Pharmaceutical Sciences, 7(6), 287–291.
[30] El-Feky, Y. A., Fares, A. R., Zayed, G., El-Telbany, R. F. A., Ahmed, K. A., & El-Telbany, D. F. A. (2021). Repurposing of Nifedipine Loaded In Situ Ophthalmic Gel as a Novel Approach for Glaucoma Treatment. Biomedicine and Pharmacotherapy, 142. https://doi.org/10.1016/j.biopha.2021.112008.
[31] Li, J., Liu, H., Liu, l. l., Cai, N. C., Xin, X. H., Liu, W. (2014). Design and Evaluation of a Brinzolamide Drug–Resin in Situ Thermosensitive Gelling System for Sustained Ophthalmic Drug Delivery. Chem. Pharm. Bull, 62(10), 1001-1008.
[32] Talaei, S., Mahboobian, M. M., & Mohammadi, M. (2020). Investigating the Ocular Toxicity Potential and Therapeutic Efficiency of In Situ Gel Nanoemulsion Formulations of Brinzolamide. Toxicology Research, 9(4), 578–587. https://doi.org/10.1093/TOXRES/TFAA066.
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2024-08-11
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