Kajian Pustaka Potensi Beberapa Tumbuhan Famili Fabaceae sebagai Antiinflamasi
DOI:
https://doi.org/10.29313/bcsp.v4i1.11380Keywords:
Antiinflamasi, Fabaceae, Anti-inflammatoryAbstract
ABSTRACT : Inflammation is a natural response of the body to infection or tissue damage, characterized by symptoms such as heat, redness, swelling, pain, and impaired function. Traditional anti-inflammatory drugs are often derived from plants. The Fabaceae family has been found to have potential anti-inflammatory properties. A systematic literature review was conducted to explore the anti-inflammatory activity of various plants from the Fabaceae family. The scientific articles were searched for in databases such as Google Scholar, Science Direct, ProQuest, SpringerLink, and PubMed. The selected articles underwent several stages of analysis to ensure accuracy and relevance. The assessment focused on plants from the Fabaceae subfamily, including Caesalpinoideae, Mimosoideae, and Faboideae, considering the plant parts used and the presence of compound groups with anti-inflammatory potential. The analysis of 22 scientific articles showed that 21 plants belonging to the Fabaceae family demonstrated anti-inflammatory properties, with the leaves being the most frequently utilized part. This is due to the presence of various compound groups, such as flavonoids and phenolics.
ABSTRAK : Inflamasi ialah proses tubuh untuk merespon infeksi atau kerusakan jaringan yang ditandai kalor, rubor, tumor, dolor, dan gangguan fungsi. Pada pengobatan inflamasi, Penggunaan obat inflamasi berasal dari tumbuhan menjadi pilihan alternatif seperti dari tumbuhan famili fabaceae. Fabaceae termasuk golongan tumbuhan famili terbesar dan diduga memiliki aktivitas farmokologis terutama antiinflamasi. Maka dilakukan penelitian mengenai potensi aktivitas antiinflamasi dari beberapa tumbuhan famili Fabaceae dengan metode systematic literature review. Pencarian data artikel ilmiah dari database yaitu Google Scholar, Science Direct, ProQuest, SpringerLink, dan PubMed. Hasil pencarian data digunakan sebagai data sekunder dan dilakukan beberapa tahapan seperti seleksi, ekstraksi dan analisis, sehingga didapatkan hasil data berupa artikel ilmiah yang akurat dan relavan. Kemudian dilakukan pengkajian mengenai beberapa tumbuhan sub famili Fabaceae (Caesalpinoideae, Mimosoideae dan Faboideae), bagian tumbuhan yang digunakan serta kandungan golongan senyawa yang berpotensi memiliki aktivitas antiinflamasi dari tumbuhan famili Fabaceae. Hasil data eligible sebanyak 22 artikel ilmiah dan menunjukan hasil pengkajian bahwa dari 21 tumbuhan famili Fabaceae memiliki aktivitas antiinflamasi. Bagian tumbuhan yang banyak digunakan untuk menentukan aktivitas antiinflamasi ialah bagian daun dan kandungan golongan senyawa banyak diidentifikasi yaitu flavonoid dan phenol.
References
Ayal, G., Belay, A., & Kahaliw, W. (2019). Evaluation of wound healing and anti-inflammatory activity of the leaves of Calpurnia aurea (Ait.) Benth (fabaceae) in mice. Wound Medicine, 25(1). https://doi.org/10.1016/j.wndm.2019.100151
Ayéna, A. C., Anani, K., Dosseh, K., Agbonon, A., & Gbeassor, M. (2021). Comparative Study of Antimicrobial, Anti-Inflammatory, and Antioxidant Activities of Different Parts from Pterocarpus Santalinoides l’Her. Ex. DC (Fabaceae). Evidence-Based Complementary and Alternative Medicine, 2021. https://doi.org/10.1155/2021/8938534
Azam, S., Huda, A. F., Shams, K., Ansari, P., Mohamed, M. K., Hasan, M. M., Azad, A. K., Mondal, K. K., & Zaouad, S. M. (2015). Anti-inflammatory and anti-oxidant study of ethanolic extract of Mimosa pudica. Journal of Young Pharmacists, 7(3), 234–240. https://doi.org/10.5530/jyp.2015.3.14
Bakasatae, N., Kunworarath, N., Takahashi Yupanqui, C., Voravuthikunchai, S. P., & Joycharat, N. (2018). Bioactive components, antioxidant, and anti-inflammatory activities of the wood of Albizia myriophylla. Revista Brasileira de Farmacognosia, 28(4), 444–450. https://doi.org/10.1016/j.bjp.2018.05.010
Campos, J. K. L., Araújo, C. S. F., Araújo, T. F. S., Santos, A. F. S., Teixeira, J. A., Lima, V. L. M., & Coelho, L. C. B. B. (2016). Anti-inflammatory and antinociceptive activities of Bauhinia monandra leaf lectin. Biochimie Open, 2, 62–68. https://doi.org/10.1016/j.biopen.2016.03.001
Chinnapun, D., & Sakorn, N. (2022). Structural characterization and antioxidant and anti-inflammatory activities of new chemical constituent from the seeds of bambara groundnut (Vigna subterranea (L.) Verdc.). CYTA - Journal of Food, 20(1), 93–101. https://doi.org/10.1080/19476337.2022.2087741
Corwin, E. J. (2018). Handbook of pathophysiology 3th edition.
Cruz, L. A., Díaz, M. A., Gupta, M. P., López-Pérez, J. L., Mondolis, E., Morán-Pinzón, J., & Guerrero, E. (2019). Assessment of the antinociceptive and anti-inflammatory activities of the stem methanol extract of Diplotropis purpurea. Pharmaceutical Biology, 57(1), 432–436. https://doi.org/10.1080/13880209.2019.1628074
Dorland, W. A. N. (2002). Kamus Kedokteran Dorland Edisi 29 (29th ed.). EGC.
Fadilaturahmah, F., Rahayu, R., & Santoso, P. (2023). Anti-inflammatory effects of velvet bean (Mucuna pruriens L. (DC.), Fabaceae) leaf ethanolic extract against carrageenan in male mice. Journal of Research in Pharmacy, 27(4), 1524–1533. https://doi.org/10.29228/jrp.438
Faujdar, S., Sharma, S., Sati, B., Pathak, A. K., & Paliwal, S. K. (2016). Comparative analysis of analgesic and anti-inflammatory activity of bark and leaves of Acacia ferruginea DC. Beni-Suef University Journal of Basic and Applied Sciences, 5(1), 70–78. https://doi.org/10.1016/j.bjbas.2016.02.002
Goodman, G. (2003). Dasar Farmakologi Terapi : Vol. Volume 2 (Edisi 10). Kedokteran EGC.
Irsyam, A. S. D., & Priyanti, P. (2016). Suku Fabaceae Di Kampus Universitas Islam Negeri (UIN) Syarif Hidayahtullah, Jakartya, Bagian 1: Tumbuha Polong Berperawakan Pohon. Al-Kauniyah: Jurnal Biologi, 9(1). https://doi.org/10.15408/kauniyah.v9i1.3257
Isely, D., Turner, B. L., & Berry, P. E. (2018, June 4). Fabales. Https://Www.Britannica.Com/Plant/Fabales.
Katno, P. (2009). Tingkat Manfaat dan Keamanan Tanaman Obat dan Obat Tradisional. Balai Penelitian Obat Tawangmangu. Fakultas Farmasi UG.
Katzung, B. G. (2010). Farmakologi Dasar dan Klinik (Edisi X). EGC:Jakarta.
Korany, D. A., Ayoub, I. M., Labib, R. M., El-Ahmady, S. H., & Singab, A. N. B. (2021). The impact of seasonal variation on the volatile profile of leaves and stems of Brownea grandiceps (Jacq.) with evaluation of their anti-mycobacterial and anti-inflammatory activities. South African Journal of Botany, 142, 88–95. https://doi.org/10.1016/j.sajb.2021.06.013
Mani, S., Duraipandian, C., & Chidambaram, S. B. (2022). Analgesic, anti-inflammatory and acute oral toxicity profile of leaf and bark extracts of Albizia procera. BMC Complementary Medicine and Therapies, 22(1). https://doi.org/10.1186/s12906-021-03497-7
Mycek, M. J. (2001). Farmakologi Ulasan Bergambar (Edisi ke-2). Widya Medika.
Nayeem, N., Imran, M., Mohammed Basheeruddin Asdaq, S., Imam Rabbani, S., Ali Alanazi, F., Alamri, A. S., Alsanie, W. F., & Alhomrani, M. (2022). Total phenolic, flavonoid contents, and biological activities of stem extracts of Astragalus spinosus (Forssk.) Muschl. grown in Northern Border Province, Saudi Arabia. Saudi Journal of Biological Sciences, 29(3), 1277–1282. https://doi.org/10.1016/j.sjbs.2021.12.029
Neal, M. J. (2006). At a Glance Farmakologi Medis (Edisi V). Erlangga Medical Series (EMS):Jakarta.
Noufou, O., André, T., Richard, S. W., Yerbanga, S., Maminata, T., Ouédraogo, S., Hay Anne, E., Irène, G., & Pierre, G. I. (2016). Anti-inflammatory and anti-plasmodial activities of methanol extract of Pterocarpus erinaceus Poir. (Fabaceae) leaves. International Journal of Pharmacology, 12(5), 549–555. https://doi.org/10.3923/ijp.2016.549.555
Olson, J. (2003). Belajar Mudah Farmakologi . EGC.
Olubodun-Obadun, T. G., Ishola, I. O., Osumuo, C. A., & Adeyemi, O. O. (2023). Standardized seed extract of Cajanus cajan (L) Millsp. produced antinociceptive and anti-inflammatory actions through inhibition of inflammatory mediators and activation of opioidergic signaling. Phytomedicine Plus, 3(4). https://doi.org/10.1016/j.phyplu.2023.100483
Ouédraogo, N., Esther Belem-Kabré, W. L. M., Thiombiano, A. M. E., Traoré, T. K., Belemnaba, L., Ouédraogo, M., & Guissou, I. P. (2023). Anti-inflammatory Potential of Glycoside Flavonoids from Pterocarpus erinaceus Poir. (Fabaceae) Leaves. Pharmacognosy Journal, 15(4), 593–598. https://doi.org/10.5530/pj.2023.15.125
Prasathkumar, M., Raja, K., Vasanth, K., Khusro, A., Sadhasivam, S., Sahibzada, M. U. K., Gawwad, M. R. A., Al Farraj, D. A., & Elshikh, M. S. (2021). Phytochemical screening and in vitro antibacterial, antioxidant, anti-inflammatory, anti-diabetic, and wound healing attributes of Senna auriculata (L.) Roxb. leaves. Arabian Journal of Chemistry, 14(9). https://doi.org/10.1016/j.arabjc.2021.103345
Price, S. A., & Wilson, L. M. (2005). Patofisiologi Konsep Klinik Proses-Proses Penyakit (IV). EGC.
Putri, A. (2018). Keanekaragaman Genus Tumbuhan Dari Famili Fabaceae Di Selatan. Pros Semin Nas Lingkung Lahan Basah. 209–213.
Rahman, M. M., Al Noman, M. A., Khatun, S., Alam, R., Shetu, M. M. H., Talukder, E. K., Imon, R. R., Biswas, M. Y., Anis-Ul-Haque, K. M., Uddin, M. J., & Akhter, S. (2023). Evaluation of Senna tora (L.) Roxb. leaves as source of bioactive molecules with antioxidant, anti-inflammatory and antibacterial potential. Heliyon, 9(1). https://doi.org/10.1016/j.heliyon.2023.e12855
Sander, M. A. (2010). Atlas Berwarna Patologi Anatomi. Rajawali Pers:Jakarta.
Sobeh, M., Rezq, S., Sabry, O. M., Abdelfattah, M. A. O., El Raey, M. A., El-Kashak, W. A., El-Shazly, A. M., Mahmoud, M. F., & Wink, M. (2019). Albizia anthelmintica: HPLC-MS/MS profiling and in vivo anti-inflammatory, pain killing and antipyretic activities of its leaf extract. Biomedicine and Pharmacotherapy, 115. https://doi.org/10.1016/j.biopha.2019.108882
Suralkar, A. A. (2008). In – Vivo Animal Models For Evaluation of Antiinflammatory Activity. Vol.6, Article Review. 2.
Swathi, K. P., Jayaram, S., Sugumar, D., & Rymbai, E. (2021). Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea. Chinese Herbal Medicines, 13(2), 243–249. https://doi.org/10.1016/j.chmed.2020.11.004
Wilmana, P. F., & Gan S. (2012). Analgesic-Antipiretik, Analgesik Anti-Inflamasi Nonsteroid dan Obat Gangguan Sendi Lainnya. Fakultas Kedokteran Universitas Indonesia.
Yadav, E., Singh, D., Yadav, P., & Verma, A. (2018). Antioxidant and anti-inflammatory properties of Prosopis cineraria based phenolic rich ointment in wound healing. Biomedicine and Pharmacotherapy, 108, 1572–1583. https://doi.org/10.1016/j.biopha.2018.09.180
Yuniarni U., Siti H., Winda O., & Ratu C. (2015). Aktivitas Antiinflamasi Ekstrak Etanol Buah dan Daun Asam Jawa (Tamarindus Indica) Serta Kombinasinya Pada Tikus Jantan Galur Wistar. 83–88.
Yusufoglu, H. S. oliman, Alam, A., Zaghloul, A. M. ohammed, Al-salkini, M. A. yman, & Alam, P. (2014). Comparative anti-inflammatory and hepatoprotective activities of Astragalus gummifer Labill herb and roots in rats. African Journal of Traditional, Complementary, and Alternative Medicines : AJTCAM / African Networks on Ethnomedicines, 11(3), 268–274. https://doi.org/10.4314/ajtcam.v11i3.37
Zongo, E., Busuioc, A., Meda, R. N. T., Botezatu, A. V., Mihaila, M. D., Mocanu, A. M., Avramescu, S. M., Koama, B. K., Kam, S. E., Belem, H., Somda, F. L. S., Ouedraogo, C., Ouedraogo, G. A., & Dinica, R. M. (2023). Exploration of the Antioxidant and Anti-inflammatory Potential of Cassia sieberiana DC and Piliostigma thonningii (Schumach.) Milne-Redh, Traditionally Used in the Treatment of Hepatitis in the Hauts-Bassins Region of Burkina Faso. Pharmaceuticals, 16(1). https://doi.org/10.3390/ph16010133
