Efektivitas Pemberian Metformin terhadap Perbaikan Manifestasi Klinis pada Pasien Sindrom Polikistik Ovarium

  • Maulani Nurmuji Atmapratiwi Prodi Pendidikan Dokter, Fakultas Kedokteran, Universitas Islam Bandung, Indonesia
  • Lelly Yuniarti Prodi Pendidikan Dokter, Fakultas Kedokteran, Universitas Islam Bandung, Indonesia
  • Ariko Rahmat Putra Prodi Pendidikan Dokter, Fakultas Kedokteran, Universitas Islam Bandung, Indonesia
Keywords: Pil Kontrasepsi, HOMA Indeks, Metformin


Abstract. Polycystic Ovarian Syndrome (PCOS) is a common endocrine disorder characterized by ovulatory dysfunction, hyperandrogenism, and the presence of polycystic ovaries. Metformin, which is an insulin sensitizer agent, is the most widely used therapy in the management of PCOS. This research aims to explore and analyze articles discussing the effectiveness of metformin in improving clinical manifestations in polycystic ovarian syndrome patients. This research is a Scoping Review of articles published in 2012-2022 from the Pubmed, Springer Link, ScienceDirect, and Taylor and Francis databases that meet the criteria of Population (women with PCOS), Intervention (administration of metformin), Comparison (therapy other than metformin), Outcome (improvement of ovarian dysfunction and size of polycystic features, improved fertility, reduced body weight, reduced insulin resistance, improved menstrual cycle, hyperinsulinemia, hyperandrogenism, and abnormal metabolic disorders), Study (randomized controlled trials). The PRISMA diagram method was used in this research. From the four databases, 7,389 articles were obtained, which were then screened according to the inclusion criteria, feasibility test, and critical review according to the Joanna Briggs Institute checklist, resulting in 11 articles. Based on the results of the analysis of 11 articles, 10 articles stated that single metformin therapy was superior in reducing BMI, waist circumference, blood glucose, HOMA index, and improving the menstrual cycle compared to myoinositol therapy, rosiglitazone, letrozole, oral contraceptive pills, clomiphene citrate, cupping fennel seeds, and ovaries. There is 1 article that states that metformin therapy can improve ovulatory dysfunction.

Abstrak. Polycystic Ovarian Syndrome (PCOS) merupakan gangguan endokrin umum yang ditandai dengan disfungsi ovulasi, hiperandrogen, dan adanya polikistik pada ovarium. Metformin merupakan agen sensitizer insulin adalah terapi yang paling banyak digunakan dalam penatalaksanaan PCOS. Tujuan dari penelitian adalah untuk mengeksplorasi dan menganalisis artikel yang membahas efektivitas metformin terhadap perbaikan manisfestasi klinis pada pasien polycystic ovarian syndrome. Penelitian ini merupakan Scoping Review  artikel  yang terbit tahun 2012-2022 dari database Pubmed, Springer Link, SienceDirect, dan Taylor and Francis yang sesuai dengan kriteria dengan Population (wanita penderita PCOS), Intervention (pemberian metformin), Comparison (terapi selain metformin), Outcome (perbaikan disfungsi ovarium dan ukuran gambaran polikistik, perbaikan fertilitas, menurunkan berat badan, mengurangi resistensi insulin, memperbaiki siklus menstruasi, hyperinsulinemia, hiperandrogenisme, dan kelainan metabolisme abnormal), Study (randomized controlled trials). Metode diagram PRISMA digunakan dalam penelitian ini, dari keempat database didapat 7,389 artikel yang kemudian dilakukan skrinning sesuai dengan kriteria inklusi, uji kelayakan, dan telaah kritis sesuai dengan checklist Joanna Briggs Institute dihasilkan 11 artikel. Berdasarkan hasil analisis dari 11 artikel terdapat 10 artikel yang menyatakan bahwa terapi metformin tunggal lebih unggul dalam  menurunkan BMI, lingkar pinggang, glukosa darah, HOMA indeks, dan memperbaiki siklus menstruasi dibandingkan dengan terapi myoinositol, rosiglitazone, letrozole, pil kontrasepsi oral, clomiphene citrate, bekam biji adas dan ovarium.  Terdapat 1 artikel yang menyatakan bahwa terapi metformin dapat memperbaiki disfungsi ovulasi.


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